Well-differentiated fetal adenocarcinoma of the lung:: Cytomorphologic features on fine-needle aspiration with emphasis on use of β-catenin as a useful diagnostic marker
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作者:
Proctor, Lori
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机构:Emory Univ, Dept Pathol & Lab Med, Atlanta, GA 30322 USA
Proctor, Lori
Folpe, Andrew L.
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机构:Emory Univ, Dept Pathol & Lab Med, Atlanta, GA 30322 USA
Folpe, Andrew L.
Esper, Annette
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机构:Emory Univ, Dept Pathol & Lab Med, Atlanta, GA 30322 USA
Esper, Annette
Wolfenden, Linda L.
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机构:Emory Univ, Dept Pathol & Lab Med, Atlanta, GA 30322 USA
Wolfenden, Linda L.
Force, Seth
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机构:Emory Univ, Dept Pathol & Lab Med, Atlanta, GA 30322 USA
Force, Seth
Logani, Sanjay
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机构:Emory Univ, Dept Pathol & Lab Med, Atlanta, GA 30322 USA
Logani, Sanjay
机构:
[1] Emory Univ, Dept Pathol & Lab Med, Atlanta, GA 30322 USA
Well-differentiated fetal adenocarcinoma (WDFA), also known as low grade adenocarcinoma of the fetal lung type, is a rare pulmonary neoplasm now considered to be a variant of lung adenocarcinoma rather than a type of pulmonary blastoma. Upregulation of the Wnt signaling pathway with subsequent aberrant nuclear/Cytoplasmic beta-catenin expression has been recently described in these tumors providing a possible pathogenetic role for this gene in WDFA. We describe the cytomorphologic findings of a case of WDFA in a 36-yr-old female patient and emphasize the diagnostic utility of aberrant nuclear/cytoplasmic expression of beta-catenin as an adjunct to the correct preoperative recognition of this tumor on aspiration cytology.
机构:
Mem Sloan Kettering Canc Ctr, Dept Pathol, Cytol Serv, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Dept Pathol, Cytol Serv, New York, NY 10021 USA
Crapanzano, JP
;
Zakowski, MF
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机构:
Mem Sloan Kettering Canc Ctr, Dept Pathol, Cytol Serv, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Dept Pathol, Cytol Serv, New York, NY 10021 USA
机构:
Mem Sloan Kettering Canc Ctr, Dept Pathol, Cytol Serv, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Dept Pathol, Cytol Serv, New York, NY 10021 USA
Crapanzano, JP
;
Zakowski, MF
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机构:
Mem Sloan Kettering Canc Ctr, Dept Pathol, Cytol Serv, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Dept Pathol, Cytol Serv, New York, NY 10021 USA