Well-differentiated fetal adenocarcinoma of the lung:: Cytomorphologic features on fine-needle aspiration with emphasis on use of β-catenin as a useful diagnostic marker

被引:12
作者
Proctor, Lori
Folpe, Andrew L.
Esper, Annette
Wolfenden, Linda L.
Force, Seth
Logani, Sanjay
机构
[1] Emory Univ, Dept Pathol & Lab Med, Atlanta, GA 30322 USA
[2] Emory Univ, Dept Med, Atlanta, GA 30322 USA
[3] Emory Univ, Dept Surg, Atlanta, GA 30322 USA
关键词
well-differentiated fetal adenocarcinoma; beta-catenin; fine-needle aspiration;
D O I
10.1002/dc.20583
中图分类号
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号
1001 ;
摘要
Well-differentiated fetal adenocarcinoma (WDFA), also known as low grade adenocarcinoma of the fetal lung type, is a rare pulmonary neoplasm now considered to be a variant of lung adenocarcinoma rather than a type of pulmonary blastoma. Upregulation of the Wnt signaling pathway with subsequent aberrant nuclear/Cytoplasmic beta-catenin expression has been recently described in these tumors providing a possible pathogenetic role for this gene in WDFA. We describe the cytomorphologic findings of a case of WDFA in a 36-yr-old female patient and emphasize the diagnostic utility of aberrant nuclear/cytoplasmic expression of beta-catenin as an adjunct to the correct preoperative recognition of this tumor on aspiration cytology.
引用
收藏
页码:39 / 42
页数:4
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