Rh(III)-Catalyzed Synthesis of Multisubstituted Isoquinolines from Benzylamines and Diazo Compounds

被引：14

作者：

Lin, Xing ^{[1
]}

Chauvin, Remi ^{[1
,2
,3
]}

Yu, Yunliang ^{[1
]}

Wang, Lianhui ^{[1
]}

Xu, Linhua ^{[1
]}

Cui, Xiuling ^{[1
]}

机构：

[1] Huaqiao Univ, Sch Biomed Sci, Key Lab Xiamen Marine & Gene Drugs, Engn Res Ctr Mol Med,Minist EduC,Key Lab Fujian M, Xiamen 361021, Peoples R China

[2] CNRS, LCC, 205 Route Narbonne,BP 44099, F-31077 Toulouse, France

[3] Univ Toulouse, UPS, INPT, F-31077 Toulouse 4, France

来源：

CHEMISTRYSELECT | 2017年 / 2卷 / 08期

关键词：

Benzylamine; Diazo compounds; Isoquinolines; Rhodium; METAL-FREE CONDITIONS; C-H ACTIVATION; REGIOSPECIFIC SYNTHESIS; IRIDIUM COMPLEXES; ANNULATION; ALKYNES; DERIVATIVES; CYCLIZATION; BENZAMIDES; BOND;

D O I：

10.1002/slct.201700270

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Multisubstituted isoquinolines have been prepared by Rh(III)-catalyzed cyclization of benzylamines with diazo compounds via aryl C-H bond activation using molecular oxygen from air as an oxidant. This method features mild reaction conditions, simple catalytic system, tolerance of a broad range of substrates, high efficiency and regioselectivity.

引用

页码：2383 / 2387

页数：5

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