Point-of-care Diagnostic Tools to Detect Circulating MicroRNAS as Biomarkers of Disease

被引:21
|
作者
Vaca, Luis [1 ]
机构
[1] Univ Nacl Autonoma Mexico, Inst Fisiol Celular, Mexico City 04510, DF, Mexico
来源
SENSORS | 2014年 / 14卷 / 05期
关键词
microRNAs; exosomes; fluids; polymerase chain reaction (PCR); microarrays; diagnostics; ACUTE KIDNEY INJURY; MULTIVESICULAR BODY; MESSENGER-RNAS; NEW-GENERATION; CANCER; PERSPECTIVES; CHALLENGES; EXOSOME; MIRNAS; SNARE;
D O I
10.3390/s140509117
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
MicroRNAs or miRNAs are a form of small non-coding RNAs (ncRNAs) of 19-22 nucleotides in length in their mature form. miRNAs are transcribed in the nucleus of all cells from large precursors, many of which have several kilobases in length. Originally identified as intracellular modulators of protein synthesis via posttranscriptional gene silencing, more recently it has been found that miRNAs can travel in extracellular human fluids inside specialized vesicles known as exosomes. We will be referring to this miRNAs as circulating microRNAs. More interestingly, the miRNA content inside exosomes changes during pathological events. In the present review we analyze the literature about circulating miRNAs and their possible use as biomarkers. Furthermore, we explore their future in point-of-care (POC) diagnostics and provide an example of a portable POC apparatus useful in the detection of circulating miRNAs.
引用
收藏
页码:9117 / 9131
页数:15
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