Mechanisms, Hallmarks, and Implications of Stem Cell Quiescence

被引：108

作者：

Cho, Inchul J. ^{[1
]}

Lui, Prudence PokWai ^{[1
]}

Obajdin, Jana ^{[1
]}

Riccio, Federica ^{[1
]}

Stroukov, Wladislaw ^{[1
]}

Willis, Thea Louise ^{[1
]}

Spagnoli, Francesca ^{[1
]}

Watt, Fiona M. ^{[1
]}

机构：

[1] Kings Coll London, Guys Hosp, Ctr Stem Cells & Regenerat Med, Floor 28,Tower Wing, London SE1 9RT, England

来源：

STEM CELL REPORTS | 2019年 / 12卷 / 06期

基金：

英国惠康基金;

关键词：

SELF-RENEWAL; SKELETAL-MUSCLE; EXTRACELLULAR-MATRIX; SATELLITE CELLS; AUTOPHAGY MAINTAINS; NICHE; CYCLE; GROWTH; BONE; ACTIVATION;

D O I：

10.1016/j.stemcr.2019.05.012

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Cellular quiescence is a dormant but reversible cellular state in which cell-cycle entry and proliferation are prevented. Recent studies both in vivo and in vitro demonstrate that quiescence is actively maintained through synergistic interactions between intrinsic and extrinsic signals. Subtypes of adult mammalian stem cells can be maintained in this poised, quiescent state, and subsequently reactivated upon tissue injury to restore homeostasis. However, quiescence can become deregulated in pathological settings. In this review, we discuss the recent advances uncovering intracellular signaling pathways, transcriptional changes, and extracellular cues within the stem cell niche that control induction and exit from quiescence in tissue stem cells. We discuss the implications of quiescence as well as the pharmacological and genetic approaches that are being explored to either induce or prevent quiescence as a therapeutic strategy.

引用

页码：1190 / 1200

页数：11

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