Targeting the MDM2/p53 pathway in gastrointestinal stromal tumors: Therapeutic potential

被引：1
|
作者：
Henze, Jorn
Muhlenberg, Thomas
Simon, Susanne
Fletcher, Jonathan A.
Schuler, Martin
Bauer, Sebastian
机构：
来源：
MOLECULAR CANCER THERAPEUTICS | 2009年 / 8卷 / 12期
关键词：
D O I：
10.1158/1535-7163.TARG-09-C154
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
C154
引用
收藏
页数：3
相关论文
共 50 条
  • [1] MDM2 GENE AMPLIFICATION AND P53 EXPRESSION IN GASTROINTESTINAL STROMAL TUMORS
    SHARMA, S
    GANSLER, T
    COHEN, C
    DEROSE, P
    ABBOTT, K
    HUNTER, S
    FRITSCH, C
    GRAMLICH, T
    LABORATORY INVESTIGATION, 1994, 70 (01) : A67 - A67
  • [2] Gastrointestinal Stromal Tumors: Clinical Significance of p53 Expression, MDM2 Amplification, and KIT Mutation Status
    Wallander, Michelle L.
    Layfield, Lester J.
    Tripp, Sheryl R.
    Schmidt, Robert L.
    APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY, 2013, 21 (04) : 308 - 312
  • [3] The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2
    Stevenson, Lauren F.
    Sparks, Alison
    Allende-Vega, Nerea
    Xirodimas, Dimitris P.
    Lane, David P.
    Saville, Mark K.
    EMBO JOURNAL, 2007, 26 (04): : 976 - 986
  • [4] Targeting the p53–MDM2 interaction to treat cancer
    C Klein
    L T Vassilev
    British Journal of Cancer, 2004, 91 : 1415 - 1419
  • [5] p53 Modulation as a Therapeutic Strategy in Gastrointestinal Stromal Tumors
    Henze, Joern
    Muehlenberg, Thomas
    Simon, Susanne
    Grabellus, Florian
    Rubin, Brian
    Taeger, Georg
    Schuler, Martin
    Treckmann, Juergen
    Debiec-Rychter, Maria
    Taguchi, Takahiro
    Fletcher, Jonathan A.
    Bauer, Sebastian
    PLOS ONE, 2012, 7 (05):
  • [6] Mdm2 and the p53 pathway in human pituitary adenomas
    Suliman, M
    Royds, J
    Cullen, D
    Timperley, W
    Powell, T
    Battersby, R
    Jones, TH
    CLINICAL ENDOCRINOLOGY, 2001, 54 (03) : 317 - 325
  • [7] P53 Mdm2 Inhibitors
    Khoury, Kareem
    Doemling, Alex
    CURRENT PHARMACEUTICAL DESIGN, 2012, 18 (30) : 4668 - 4678
  • [8] MDM2与p53
    金晶
    刘耕陶
    癌症, 2001, (06) : 663 - 666
  • [9] p53 as a biomarker and potential target in gastrointestinal stromal tumors
    Wu, Chiao-En
    Chen, Chiao-Ping
    Huang, Wen-Kuan
    Pan, Yi-Ru
    Aptullahoglu, Erhan
    Yeh, Chun-Nan
    Lunec, John
    FRONTIERS IN ONCOLOGY, 2022, 12
  • [10] MDM2 and BCL-2: to p53 or not to p53?
    Wang, Eunice S.
    BLOOD, 2023, 141 (11) : 1237 - 1238
12345