Pharmacokinetics in cancer chemotherapy

被引：22

作者：

Garattini, Silvio ^{[1
]}

机构：

[1] Ist Ric Farmacol Mario Negri, I-20157 Milan, Italy

来源：

EUROPEAN JOURNAL OF CANCER | 2007年 / 43卷 / 02期

关键词：

D O I：

10.1016/j.ejca.2006.10.015

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A review of some of the significant issues, such as the host and tumor factors that determine drug concentrations in tumors and the relationship of pharmacokinetics with cancer chemotherapy is presented. The review focuses on issues such as primary and metastatic tissues, penetration of drugs into various layers of a tumor, importance of metabolism in the effects of drugs, cellular and intracellular transport of antitumoral drugs and drug resistance. Studies in animals have revealed that blood concentrations of antitumoral agents are sometimes unable to predict their concentrations in tissues in tumors and the concentrations of antitumoral agents in normal tissues are higher than in the primary tumors. It is also observed that metabolism leads to the formation of inactive metabolites and the metabolic steps involved in the inactivation of anticancer agents is important to find inhibitors to increase their availability in neoplastic tissues.

引用

页码：271 / 282

页数：12

共 195 条

[1] INCREASED INTRATUMOR CONCENTRATION OF FLUORESCEIN-ISOTHIOCYANATE-LABELED NEOCARZINOSTATIN IN RATS UNDER ANGIOTENSIN-INDUCED HYPERTENSION [J].

ABE, I ;

HORI, K ;

SAITO, S ;

TANDA, S ;

LI, YL ;

SUZUKI, M .

JAPANESE JOURNAL OF CANCER RESEARCH, 1988, 79 (07) :874-879

[2] Molecular evolution of the equilibrative nucleoside transporter family: Identification of novel family members in prokaryotes and eukaryotes [J].

Acimovic, Y ;

Coe, IR .

MOLECULAR BIOLOGY AND EVOLUTION, 2002, 19 (12) :2199-2210

[3] Liposomes - Opportunities in drug delivery [J].

Allen, TM .

DRUGS, 1997, 54 (Suppl 4) :8-14

[4] Biochemical, cellular, and pharmacological aspects of the multidrug transporter [J].

Ambudkar, SV ;

Dey, S ;

Hrycyna, CA ;

Ramachandra, M ;

Pastan, I ;

Gottesman, MM .

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, 1999, 39 :361-398

[5] CYTOTOXIC EFFECT OF THIACARBOCYANINE DYES ON HUMAN COLON-CARCINOMA CELLS AND INHIBITION OF BOVINE HEART MITOCHONDRIAL NADH-UBIQUINONE REDUCTASE-ACTIVITY VIA A ROTENONE-TYPE MECHANISM BY 2 OF THE DYES [J].

ANDERSON, WM ;

DELINCK, DL ;

BENNINGER, L ;

WOOD, JM ;

SMILEY, ST ;

CHEN, LB .

BIOCHEMICAL PHARMACOLOGY, 1993, 45 (03) :691-696

[6]

[Anonymous], 1992, LYMPHAT TRANSP DRUGS

[7]

Arboix M, 1997, J PHARMACOL EXP THER, V281, P1226

[8] Localization of breast cancer resistance protein (BCRP) in microvessel endothelium of human control and epileptic brain [J].

Aronica, E ;

Gorter, JA ;

Redeker, S ;

van Vliet, EA ;

Ramkema, M ;

Scheffer, GL ;

Scheper, RJ ;

van der Valk, P ;

Leenstra, S ;

Baayen, JC ;

Spliet, WGM ;

Troost, D .

EPILEPSIA, 2005, 46 (06) :849-857

[9] Determinants of drug delivery and transport to solid tumors [J].

Au, JLS ;

Jang, SH ;

Zheng, J ;

Chen, CT ;

Song, S ;

Hu, L ;

Wientjes, MG .

JOURNAL OF CONTROLLED RELEASE, 2001, 74 (1-3) :31-46

[10] The equilibrative nucleoside transporter family, SLC29 [J].

Baldwin, SA ;

Beal, PR ;

Yao, SYM ;

King, AE ;

Cass, CE ;

Young, JD .

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 2004, 447 (05) :735-743

← 1 2 3 4 5 6 7 8 9 10 →