Study of the stability of the 5-aminolevulinic acid tyrosine ester in aqueous solution

被引：2

作者：

Gay, Sandrine ^{[1
]}

Martoccia, Carla ^{[1
]}

Zellweger, Matthieu ^{[1
]}

Wang, Qian ^{[2
]}

Wagnieres, Georges ^{[1
]}

机构：

[1] Swiss Fed Inst Technol EPFL, LCOM Med Photon Grp, SB ISIC, Stn 6,CH H5, CH-1015 Lausanne, Switzerland

[2] Swiss Fed Inst Technol EPFL, LSPN, SB ISIC, CH-1015 Lausanne, Switzerland

来源：

ARKIVOC | 2014年

基金：

瑞士国家科学基金会;

关键词：

5-Aminolevulinic acid; stability; 5-aminolevulinic acid derivatives; photodynamic therapy; tyrosine ester; PHOTODYNAMIC THERAPY; PROTOPORPHYRIN-IX; DERIVATIVES;

D O I：

10.3998/ark.5550190.p008.469

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Photodynamic therapy based on photoactivable porphyrins (PAPs) can treat various dermatological conditions. The side-effects as well as the non-selective or insufficient accumulation of PAPs in the targeted tissues limit performances. We studied the stability in solution at different temperatures (21 degrees C; 4 degrees C), different pH values (7.5; 2.0), and as a function of time of 5-aminolevulinic acid's Tyrosine-ester, a molecule presenting interesting properties to selectively produce PAPs in blood vessels after topical application. Solutions of this precursor can be kept up to 24 h at refrigerated temperatures and under acidic pH. At room temperature or physiological pH, they must be prepared minutes before their use.

引用

页码：228 / 238

页数：11

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