Simultaneous enzymatic synthesis of (S)-3-fluoroalanine and (R)-3-fluorolactic acid

被引：34

作者：

Gonçalves, LPB ^{[1
]}

Antunes, OAC ^{[1
]}

Pinto, GF ^{[1
]}

Oestreicher, EG ^{[1
]}

机构：

[1] Univ Fed Rio de Janeiro, Inst Quim, BR-21945970 Rio De Janeiro, Brazil

来源：

TETRAHEDRON-ASYMMETRY | 2000年 / 11卷 / 07期

关键词：

D O I：

10.1016/S0957-4166(00)00096-3

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A coupled enzymatic system for the simultaneous synthesis of (S)-3-fluoroalanine (1a) and (R)-3-fluorolactic acid (3) with L-alanine dehydrogenase (L-AlaDH) from Bacillus subtilis and rabbit muscle L-lactate dehydrogenase (L-LDH) using rac-1 and NAD(+) is described. Analysis of isolated products of the laboratory preparative scale process revealed la in 60% yield and 88% ee and 3 in 80% yield and over 99% ee. The compounds la and 3 represent chiral building blocks for the synthesis of several products with pharmacological activity. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：1465 / 1468

页数：4

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