Necroptosis in development, inflammation and disease

被引：789

作者：

Weinlich, Ricardo ^{[1
]}

Oberst, Andrew ^{[2
]}

Beere, Helen M. ^{[3
]}

Green, Douglas R. ^{[3
]}

机构：

[1] Hosp Israelita Albert Einstein, BR-05652900 Sao Paulo, SP, Brazil

[2] Univ Washington, Dept Immunol, Seattle, WA 98109 USA

[3] St Jude Childrens Res Hosp, Dept Immunol, Memphis, TN 38105 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2017年 / 18卷 / 02期

基金：

美国国家卫生研究院;

关键词：

NF-KAPPA-B; TUMOR-NECROSIS-FACTOR; MIXED LINEAGE KINASE; DOMAIN-LIKE PROTEIN; NONAPOPTOTIC CELL-DEATH; TNF RECEPTOR 1; PROGRAMMED NECROSIS; NLRP3; INFLAMMASOME; RIP1; KINASE; PSEUDOKINASE MLKL;

D O I：

10.1038/nrm.2016.149

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

In the early 2000s, receptor-interacting serine/threonine protein kinase 1 (RIPK1), a molecule already recognized as an important regulator of cell survival, inflammation and disease, was attributed an additional function: the regulation of a novel cell death pathway that came to be known as necroptosis. Subsequently, the related kinase RIPK3 and its substrate mixed-lineage kinase domain-like protein (MLKL) were also implicated in the necroptotic pathway, and links between this pathway and apoptosis were established. In this Timeline article, we outline the discoveries that have helped to identify the roles of RIPK1, RIPK3, MLKL and other regulators of necroptosis, and how they interact to determine cell fate.

引用

页码：127 / 136

页数：10

共 155 条

[1] The Pseudokinase MLKL and the Kinase RIPK3 Have Distinct Roles in Autoimmune Disease Caused by Loss of Death-Receptor-Induced Apoptosis [J].

Alvarez-Diaz, Silvia ;

Dillon, Christopher P. ;

Lalaoui, Najoua ;

Tanzer, Maria C. ;

Rodriguez, Diego A. ;

Lin, Ann ;

Lebois, Marion ;

Hakem, Razq ;

Josefsson, Emma C. ;

O'Reilly, Lorraine A. ;

Silke, John ;

Alexander, Warren S. ;

Green, Douglas R. ;

Strasser, Andreas .

IMMUNITY, 2016, 45 (03) :513-526

[2] Caspase-8 as an Effector and Regulator of NLRP3 Inflammasome Signaling [J].

Antonopoulos, Christina ;

Russo, Hana M. ;

El Sanadi, Caroline ;

Martin, Bradley N. ;

Li, Xiaoxia ;

Kaiser, William J. ;

Mocarski, Edward S. ;

Dubyak, George R. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2015, 290 (33) :20167-20184

[3] Proapoptotic Chemotherapeutic Drugs Induce Noncanonical Processing and Release of IL-1β via Caspase-8 in Dendritic Cells [J].

Antonopoulos, Christina ;

El Sanadi, Caroline ;

Kaiser, William J. ;

Mocarski, Edward S. ;

Dubyak, George R. .

JOURNAL OF IMMUNOLOGY, 2013, 191 (09) :4789-4803

[4] Clostridium perfringens Beta-Toxin Induces Necrostatin-Inhibitable, Calpain-Dependent Necrosis in Primary Porcine Endothelial Cells [J].

Autheman, Delphine ;

Wyder, Marianne ;

Popoff, Michel ;

D'Herde, Katharina ;

Christen, Stephan ;

Posthaus, Horst .

PLOS ONE, 2013, 8 (05)

[5] A FADD-dependent innate immune mechanism in mammalian cells [J].

Balachandran, S ;

Thomas, E ;

Barber, GN .

NATURE, 2004, 432 (7015) :401-405

[6] FADD and caspase-8 control the outcome of autophagic signaling in proliferating T cells [J].

Bell, Bryan D. ;

Leverrier, Sabrina ;

Weist, Brian M. ;

Newton, Ryan H. ;

Arechiga, Adrian F. ;

Luhrs, Keith A. ;

Morrissette, Naomi S. ;

Walsh, Craig M. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (43) :16677-16682

[7] Cutting Edge: RIP1 Kinase Activity Is Dispensable for Normal Development but Is a Key Regulator of Inflammation in SHARPIN-Deficient Mice [J].

Berger, Scott B. ;

Kasparcova, Viera ;

Hoffman, Sandy ;

Swift, Barb ;

Dare, Lauren ;

Schaeffer, Michelle ;

Capriotti, Carol ;

Cook, Michael ;

Finger, Joshua ;

Hughes-Earle, Angela ;

Harris, Philip A. ;

Kaiser, William J. ;

Mocarski, Edward S. ;

Bertin, John ;

Gough, Peter J. .

JOURNAL OF IMMUNOLOGY, 2014, 192 (12) :5476-5480

[8] The Adaptor Protein FADD Protects Epidermal Keratinocytes from Necroptosis In Vivo and Prevents Skin Inflammation [J].

Bonnet, Marion C. ;

Preukschat, Daniela ;

Welz, Patrick-Simon ;

van Loo, Geert ;

Ermolaeva, Maria A. ;

Bloch, Wilhelm ;

Haase, Ingo ;

Pasparakis, Manolis .

IMMUNITY, 2011, 35 (04) :572-582

[9] Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis [J].

Cai, Zhenyu ;

Jitkaew, Siriporn ;

Zhao, Jie ;

Chiang, Hsueh-Cheng ;

Choksi, Swati ;

Liu, Jie ;

Ward, Yvona ;

Wu, Ling-gang ;

Liu, Zheng-Gang .

NATURE CELL BIOLOGY, 2014, 16 (01) :55-+

[10] Antigen-mediated T cell expansion regulated by parallel pathways of death [J].

Ch'en, Irene L. ;

Beisner, Daniel R. ;

Degterev, Alexei ;

Lynch, Candace ;

Yuan, Junying ;

Hoffmann, Alexander ;

Hedrick, Stephen M. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (45) :17463-17468

← 1 2 3 4 5 6 7 8 9 10 →