HPV post-infection microenvironment and cervical cancer

被引：156

作者：

Yuan, Yi ^{[1
,2
]}

Cai, Xushan ^{[3
]}

Shen, Fangrong ^{[4
]}

Ma, Feng ^{[1
]}

机构：

[1] Suzhou Inst Syst Med, Suzhou 215123, Peoples R China

[2] Tongji Univ, Shanghai Tongji Hosp, Sch Med, Dept Lab Med, Shanghai 200065, Peoples R China

[3] Maternal & Child Hlth Hosp Jiading Dist, Dept Clin Lab, Shanghai 201821, Peoples R China

[4] Soochow Univ, Affiliated Hosp 1, Dept Obstet & Gynecol, Suzhou 215001, Peoples R China

来源：

CANCER LETTERS | 2021年 / 497卷

基金：

中国国家自然科学基金;

关键词：

Papillomaviruses; Sexually transmitted virus; HPV infection; Immune regulation; PIM; PAPILLOMAVIRUS TYPE-16 E6; HIGH-RISK HPV; E7; ONCOPROTEINS; IMMUNE EVASION; IFN-GAMMA; DIFFERENTIALLY MODULATE; PERIPHERAL-BLOOD; CELLULAR REDOX; E2; PROTEIN; E-CADHERIN;

D O I：

10.1016/j.canlet.2020.10.034

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Human papillomavirus (HPV) is the most common sexually transmitted virus worldwide. More than 99% of cervical cancer cases are associated with certain types of HPVs, termed high-risk types. In addition to the wellknown transformative properties, HPVs-infected cells actively instruct the local milieu and create a supportive post-infection microenvironment (PIM), which is becoming recognized as a key factor for the viral persistence, propagation, and malignant progression. The PIM is initiated and established via a complex interplay among virus-infected cells, immune cells, and host stroma, as well as their derived components including chemokines, cytokines, extracellular vesicles, and metabolites. In this review, we summarize the current understanding of these key components, characteristics, and effects of the PIM, and highlights the prospect of targeting the PIM as a potential strategy to improve therapeutic outcomes for cervical cancer.

引用

页码：243 / 254

页数：12

共 129 条

[11] Interleukin-10 and prostaglandin E2 have complementary but distinct suppressive effects on Toll-like receptor-mediated dendritic cell activation in ovarian carcinoma [J].

Brencicova, Eva ;

Jagger, Ann L. ;

Evans, Hayley G. ;

Georgouli, Mirella ;

Laios, Alex ;

Montalto, Steve Attard ;

Mehra, Gautam ;

Spencer, Jo ;

Ahmed, Ahmed A. ;

Raju-Kankipati, Shanti ;

Taams, Leonie S. ;

Diebold, Sandra S. .

PLOS ONE, 2017, 12 (04)

[12] HPV-16 E5 down-regulates expression of surface HLA class I by CD8 T cells [J].

Campo, M. S. ;

Graham, S. V. ;

Cortese, M. S. ;

Ashrafi, G. H. ;

Araibi, E. H. ;

Dornan, E. S. ;

Miners, K. ;

Nunes, C. ;

Man, S. .

VIROLOGY, 2010, 407 (01) :137-142

[13] Mortality impact of achieving WHO cervical cancer elimination targets: a comparative modelling analysis in 78 low-income and lower-middle-income countries [J].

Canfell, Karen ;

Kim, Jane J. ;

Brisson, Marc ;

Keane, Adam ;

Simms, Kate T. ;

Caruana, Michael ;

Burger, Emily A. ;

Martin, Dave ;

Nguyen, Diep T. N. ;

Benard, Elodie ;

Sy, Stephen ;

Regan, Catherine ;

Drolet, Melanie ;

Gingras, Guillaume ;

Laprise, Jean-Francois ;

Torode, Julie ;

Smith, Megan A. ;

Fidarova, Elena ;

Trapani, Dario ;

Bray, Freddie ;

Ilbawi, Andre ;

Broutet, Nathalie ;

Hutubessy, Raymond .

LANCET, 2020, 395 (10224) :591-603

[14] Increased High-Risk Human Papillomavirus Viral Load Is Associated With Immunosuppressed Microenvironment and Predicts a Worse Long-Term Survival in Cervical Cancer Patients [J].

Cao, Meng ;

Wang, Ying ;

Wang, Depu ;

Duan, Yixin ;

Hong, Wei ;

Zhang, Nana ;

Shah, Walayat ;

Wang, Yili ;

Chen, Hongwei .

AMERICAN JOURNAL OF CLINICAL PATHOLOGY, 2020, 153 (04) :502-512

[15] Human papillomavirus causes an angiogenic switch in keratinocytes which is sufficient to alter endothelial cell behavior [J].

Chen, W. ;

Li, F. ;

Mead, L. ;

White, H. ;

Walker, J. ;

Ingram, D. A. ;

Roman, A. .

VIROLOGY, 2007, 367 (01) :168-174

[16] Clinical Significance of CD163+and CD68+Tumor-associated Macrophages in High-risk HPV-related Cervical Cancer [J].

Chen, Xiao-Jing ;

Han, Ling-Fei ;

Wu, Xiang-Guang ;

Wei, Wen-Fei ;

Wu, Lan-Fang ;

Yi, Hong-Yan ;

Yan, Rui-Ming ;

Bai, Xiang-yang ;

Zhong, Mei ;

Yu, Yan-hong ;

Liang, Li ;

Wang, Wei .

JOURNAL OF CANCER, 2017, 8 (18) :3868-3875

[17] Antiviral and Immunomodulatory Properties of Antimicrobial Peptides Produced by Human Keratinocytes [J].

Chessa, Celine ;

Bodet, Charles ;

Jousselin, Clement ;

Wehbe, Michel ;

Leveque, Nicolas ;

Garcia, Magali .

FRONTIERS IN MICROBIOLOGY, 2020, 11

[18] Human papillomavirus E6 and E7 oncoproteins affect the expression of cancer-related microRNAs: additional evidence in HPV-induced tumorigenesis [J].

Chiantore, Maria Vincenza ;

Mangino, Giorgio ;

Iuliano, Marco ;

Zangrillo, Maria Simona ;

De Lillis, Ilaria ;

Vaccari, Gabriele ;

Accardi, Rosita ;

Tommasino, Massimo ;

Cabezas, Sandra Columba ;

Federico, Maurizio ;

Fiorucci, Gianna ;

Romeo, Giovanna .

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 2016, 142 (08) :1751-1763

[19]

Choi KS, 2003, J BIOCHEM MOL BIOL, V36, P120

[20] Suppression of Antitumor Immune Responses by Human Papillomavirus through Epigenetic Downregulation of CXCL14 [J].

Cicchini, Louis ;

Westrich, Joseph A. ;

Xu, Tao ;

Vermeer, Daniel W. ;

Berger, Jennifer N. ;

Clambey, Eric T. ;

Lee, Denis ;

Song, John I. ;

Lambert, Paul F. ;

Greer, Robert O. ;

Lee, John H. ;

Pyeon, Dohun .

MBIO, 2016, 7 (03)

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