Two new neo-clerodane diterpenoid alkaloids from Scutellaria barbata with cytotoxic activities

被引：30

作者：

Dai, Sheng-Jun ^{[1
]}

Peng, Wei-Bing ^{[2
]}

Shen, Li ^{[2
]}

Zhang, De-Wu ^{[1
]}

Ren, Yan ^{[1
]}

机构：

[1] Yantai Univ, Sch Pharmaceut Sci, Yantai 264005, Peoples R China

[2] Ocean Univ China, Key Lab Marine Drugs, Chinese Minist Educ, Inst Marine Drug & Food, Qingdao 266003, Peoples R China

来源：

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2009年 / 11卷 / 05期

关键词：

Scutellaria barbata D; Don; neo-clerodane diterpenoid alkaloid; scutebarbatine O; 6-O-nicotinoylscutebarbatine G; cytotoxic activity; RESISTANT; CELLS;

D O I：

10.1080/10286020902845652

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two new neo-clerodane diterpenoid alkaloids, scutebarbatine O (1) and 6-O-nicotinoylscutebarbatine G (2), were isolated from the whole plant of Scutellaria barbata. Their structures were elucidated by spectroscopic methods including extensive 1D and 2D NMR analyses. In vitro, compounds 1 and 2 showed cytotoxic activities against three human tumor cell lines, namely, HONE-1 nasopharyngeal, KB oral epidermoid carcinoma, and HT29 colorectal carcinoma cells, and with IC50 values in the range of 2.1-5.7M.

引用

页码：451 / 456

页数：6

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