t-BuOK-Mediated Transition-Metal-Free Direct Olefination and Alkylation of Methyl N-Heteroarenes with Primary Alcohols under Control of Temperature

被引：4

作者：

Su, Fangyao ^{[1
]}

Lai, Miao ^{[1
]}

Zhao, Mingqin ^{[1
]}

Song, Mingzhou ^{[1
]}

Hu, Xin ^{[1
]}

Zhang, Junqin ^{[1
]}

机构：

[1] Henan Agr Univ, Coll Tobacco Sci, Flavors & Fragrance Engn & Technol Res Ctr Henan, 95 Wenhua Rd, Zhengzhou 450002, Peoples R China

来源：

CHEMISTRYSELECT | 2022年 / 7卷 / 06期

关键词：

methyl-substituted N-heteroarenes; primary alcohols; t-BuOK-mediated; olefination; alkylation; CATALYZED ALKYLATION; FLAVOR PRECURSORS; ALPHA-ALKYLATION; THERMAL-BEHAVIOR; C-ALKYLATION; AMINES; HETEROAROMATICS; PYROLYSIS; CHEMISTRY; AZAARENES;

D O I：

10.1002/slct.202104454

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Transition-metal-free, temperature-controlled chemoselectivities of alkenylazaarenes and alkylazaarenes through t-BuOK/18-crown-6 promoted functionalization reaction of methyl-substituted N-heteroarenes with primary alcohols has been established. Following the methodology, a variety of olefinated and alkylated N-heteroarenes have been efficiently obtained. To understand the mechanism of the reactions, various control and kinetic experiments were carried out.

引用

页数：6

共 7 条

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