Design of spray dried ternary solid dispersions comprising itraconazole, soluplus and HPMCP: Effect of constituent compositions

被引：49

作者：

Davis, Mark T. ^{[1
]}

Potter, Catherine B. ^{[1
]}

Mohammadpour, Maryam ^{[2
]}

Albadarin, Ahmad B. ^{[1
]}

Walker, Gavin M. ^{[1
]}

机构：

[1] Univ Limerick, BernalInst, SSPC, Limerick, Ireland

[2] NUI, Sch Pharm, Cavanagh Pharm Bldg, Cork, Ireland

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2017年 / 519卷 / 1-2期

基金：

爱尔兰科学基金会;

关键词：

Itraconazole; Soluplus; HPMCP; Ternary; Amorphous; Spray drying; IMPROVE ORAL BIOAVAILABILITY; DRUG; FORMULATION;

D O I：

10.1016/j.ijpharm.2017.01.043

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A range of 17 ternary formulations of itraconazole (ITZ), HPMCP and Soluplus have been manufactured using spray drying. These amorphous solid dispersions (ASDs) were very stable against crystallisation and ITZ was found to be amorphous in all formulations after one year at 40 degrees C/75% RH. A number of solid state analytical techniques including PXRD, DSC, small angle X-ray scattering, FTIR and solid state NMR were used to characterise the physicochemical properties of the ASDs following processing and storage and to assess any interactions between components. Microtrac laser scattering analysis revealed a relationship between polymer levels and particle size distribution (PSD). Dissolution studies indicated that higher Soluplus content in the formulation resulted in higher concentrations of ITZ in acidic media. (C) 2017 Elsevier B.V. All rights reserved.

引用

页码：365 / 372

页数：8

共 26 条

[1] Ultrasonic atomization for spray drying: a versatile technique for the preparation of protein loaded biodegradable microspheres [J].