Molecular Imaging with Bioconjugates in Mouse Models of Cancer

被引：28

作者：

Mather, Stephen ^{[1
,2
]}

机构：

[1] St Bartholomews Hos, Barts & London Queen Marys Sch Med & Dent, Ctr Canc Imaging, Inst Canc, London EC1A 7BE, England

[2] St Bartholomews Hos, CR UK Clin Ctr, London EC1A 7BE, England

来源：

BIOCONJUGATE CHEMISTRY | 2009年 / 20卷 / 04期

关键词：

POSITRON-EMISSION-TOMOGRAPHY; REPORTER GENE-EXPRESSION; SMALL-ANIMAL PET; IN-VIVO; TUMOR ANGIOGENESIS; ALPHA(V)BETA(3) EXPRESSION; SODIUM/IODIDE SYMPORTER; GLUCOSE-METABOLISM; DRUG DEVELOPMENT; LIVING ANIMALS;

D O I：

10.1021/bc800401x

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The definition of molecular imaging provided by the Society of Nuclear Medicine is "the visualization, characterization and measurement of biological processes at the molecular and cellular levels in humans and other living systems". This review gives an overview of the technologies available for and the potential benefits from molecular imaging at the preclinical stage. It focuses on the use of imaging probes based on bioconjugates and for reasons of brevity confines itself to discussion of applications in the field of oncology, although molecular imaging can be equally useful in many fields including cardiovascular medicine, neurosciences, infection, and others.

引用

页码：631 / 643

页数：13

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