Antihyperlipidemic Effect of Fisetin, a Bioflavonoid of Strawberries, Studied in Streptozotocin-Induced Diabetic Rats

被引：41

作者：

Prasath, Gopalan Sriram ^{[1
]}

Subramanian, Sorimuthu Pillai ^{[1
]}

机构：

[1] Univ Madras, Dept Biochem, Madras 600025, Tamil Nadu, India

来源：

JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY | 2014年 / 28卷 / 10期

关键词：

Fisetin; Streptozotocin; Diabetes; Antihyperlipidemic Property; SPRAGUE-DAWLEY RATS; FREE FATTY-ACIDS; DIETARY-FAT; METABOLIC SYNDROME; GLUCOSE-TOLERANCE; OXIDATIVE STRESS; HYPERGLYCEMIA; TISSUES; WOMEN; SERUM;

D O I：

10.1002/jbt.21583

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Chronic hyperglycemia in diabetes is associated with profound changes in lipid and lipoprotein metabolism, with resultant alterations in particle distribution within lipoprotein classes. In the present study, an attempt has been made to explore the antihyperlipidemic effect of fisetin in streptozotocin-induced experimental diabetes in rats. Upon fisetin treatment to diabetic rats, the levels of blood glucose were significantly reduced with an improvement in plasma insulin. The increased levels of lipid contents in serum, hepatic, and renal tissues observed in diabetic rats were normalized upon fisetin administration. Also, the decreased levels of high-density lipoprotein cholesterol, and increased levels of low-density lipoprotein (LDL) and very LDL (VLDL) cholesterol in serum of diabetic rats were normalized. Oil Red O staining established a large number of intracellular lipid droplets accumulation in the diabetic rats. Fisetin treatment exacerbated the degree of lipid accumulation. The results of the present study exemplify the antihyperlipidemic property of the fisetin.

引用

页码：442 / 449

页数：8

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