Contribution of Matrix Metalloproteinase-2 Promoter Genotypes to Nasopharyngeal Cancer Susceptibility and Metastasis in Taiwan

被引：18

作者：

Hsu, Shih-Wei ^{[1
,3
,4
]}

Gong, Chi-Li ^{[2
]}

Hsu, Huai-Mei ^{[1
,5
]}

Chao, Chih-Chang ^{[7
]}

Wang, Yun-Chi ^{[5
]}

Chang, Wen-Shin ^{[5
]}

Tsai, Yueh-Ting ^{[5
]}

Shih, Liang-Chun ^{[1
,6
]}

Tsai, Chia-Wen ^{[5
]}

Bau, Da-Tian ^{[1
,5
,8
]}

机构：

[1] China Med Univ, Grad Inst Biomed Sci, Taichung, Taiwan

[2] China Med Univ, Dept Physiol, Taichung, Taiwan

[3] Taichung Armed Forces Gen Hosp, Taichung, Taiwan

[4] Natl Def Med Ctr, Taipei, Taiwan

[5] China Med Univ Hosp, Terry Fox Canc Res Lab, Translat Med Res Ctr, 2 Yuh Der Rd, Taichung 404, Taiwan

[6] China Med Univ Hosp, Dept Otolaryngol, Taichung, Taiwan

[7] Natl Chengchi Univ, Inst Neurosci, Taipei, Taiwan

[8] Asia Univ, Dept Bioinformat & Med Engn, Taichung, Taiwan

来源：

CANCER GENOMICS & PROTEOMICS | 2019年 / 16卷 / 04期

关键词：

Genotype; metastasis; MMP2; nasopharyngeal cancer; susceptibility; polymorphism; Taiwan; TISSUE INHIBITOR; CARCINOMA-CELLS; ORAL-CANCER; RISK; ASSOCIATION; EXPRESSION; POLYMORPHISMS; MMP-2;

D O I：

10.21873/cgp.20133

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background/Aim: Matrix metalloproteinase 2 (MMP2) is up-regulated in many cancers. However, the association of MMP2 genotype to nasopharyngeal cancer (NPC) susceptibility in Taiwan remains elusive. Materials and Methods: In this study, the role of MMP2 promoter C-1306T (rs243865) and C-735T (rs2285053) genotypes were investigated among 208 NPC patients and 416 healthy controls, and their role in NPC staging and TNM classifications were examined. Results: There was no differential distribution as for the genotypic or allelic frequencies at MMP2 promoter C-1306T or C-735T between the control and case groups. Noticeably, those with MMP2 C-1306T CT+TT genotypes had a lower metastatic risk than those with CC (p=0.0295). As for staging, T and N classifications, there was no differential distribution in C-1306T genotypes (p>0.05). Also, there was no differential distribution of C-735T genotypes according to different behavioral/clinicopathological characteristics. Conclusion: CT and TT genotypes at MMP2 C-1306T were associated with a significantly decreased risk of NPC metastasis.

引用

页码：287 / 292

页数：6

共 29 条

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