Novel Carbon Dots Derived from Cirsii Japonici Herba Carbonisata and Their Haemostatic Effect

被引：35
作者：
Wang, Yongzhi [1 ]
Kong, Hui [2 ]
Liu, Xiaoman [2 ]
Luo, Juan [1 ]
Xiong, Wei [1 ]
Zhu, Yafan [2 ]
Zhang, Yaxue [2 ]
Zhang, Yihe [2 ]
Zhao, Yan [2 ]
Qu, Huihua [3 ]
机构：
[1] Beijing Univ Chinese Med, Sch Chinese Mat Med, Beijing 100029, Peoples R China
[2] Beijing Univ Chinese Med, Sch Basic Med Sci, Beijing 100029, Peoples R China
[3] Beijing Univ Chinese Med, Ctr Sci Expt, Beijing 100029, Peoples R China
来源：
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY | 2018年 / 14卷 / 09期
关键词：
Bioactivity; Carbon Dots; Cell Counting Kit; Bleeding Time; Mechanism; Coagulation Parameters; Platelets; DRUG-DELIVERY; QUANTUM DOTS; FERRIC ION; FLUORESCENCE; GREEN;
D O I：
10.1166/jbn.2018.2613
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
The purpose of this study was to explore the haemostatic effect of novel carbon dots (CDs) derived from Cirsii Japonici Herba Carbonisata (CJHC). Transmission electron microscopy (TEM), high-resolution TEM, Fourier transform infrared spectroscopy, ultraviolet-visible spectroscopy, fluorescence spectroscopy, X-ray photoelectron spectroscopy, high performance liquid chromatography and a cell counting kit-8 assay of CJHC-CDs were performed. Then the haemostatic effect of this CJHC-CDs was studied in bleeding mouse models. To explore their related haemostatic mechanism, coagulation parameters and platelets (PLT) were measured. The CJHC-CDs ranged in diameter from 2 to 11 nm and had a quantum yield of 0.63%. They exhibited no toxicity up to concentrations of 5752 mu g/mL. After administration, mice had a significantly shortened bleeding time and the coagulation parameters and PLT significantly increased. These results showed the definite haemostatic effect of CJHC-CDs.
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收藏
页码：1635 / 1644
页数：10
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