Pois(s)on - It's a question of dose ...

被引：97

作者：

Fehse, B

Kustikova, OS

Bubenheim, M

Baum, C

机构：

[1] Univ Hamburg, Hosp Eppendorf, Bone Marrow Transplantat Ctr, D-20251 Hamburg, Germany

[2] Univ Hamburg, Hosp Eppendorf, Inst Med Biometry & Epidemiol, D-20251 Hamburg, Germany

[3] Hannover Med Sch, Dept Hematol & Oncol, D-3000 Hannover, Germany

[4] Cincinnati Childrens Res Fdn, Div Expt Hematol, Cincinnati, OH USA

来源：

GENE THERAPY | 2004年 / 11卷 / 11期

关键词：

D O I：

10.1038/sj.gt.3302270

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In summary, integrating gene transfer vectors have been associated with potentially dangerous genetic lesions. To decrease the resulting potential risk, the number of vector insertions should be limited. Statistical methods as suggested here may be very useful as a general guide to predict insertion frequency distribution, but further experiments addressing this question for different vectors are strongly encouraged. Eventually, the oncogenic risk will have to be determined for each vector-transgene-host cell combination of interest. © 2004 Nature Publishing Group All rights reserved.

引用

页码：879 / 881

页数：3

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