Polysialic acid biosynthesis and production in Escherichia coli: current state and perspectives

被引：21

作者：

Lin, Bai-Xue ^{[1
]}

Qiao, Yu ^{[2
]}

Shi, Bo ^{[2
]}

Tao, Yong ^{[1
]}

机构：

[1] Chinese Acad Sci, Inst Microbiol, CAS Key Lab Microbial Physiol & Metab Engn, 1 West Beichen Rd, Beijing 100101, Peoples R China

[2] Chinese Acad Agr Sci, Feed Res Inst, Beijing 100081, Peoples R China

来源：

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY | 2016年 / 100卷 / 01期

关键词：

Polysialic acid biosynthesis; Escherichia coli; Metabolic engineering; Process engineering; D-NEURAMINIC ACID; FED-BATCH FERMENTATION; SIALIC-ACID; ENHANCED PRODUCTION; COLOMINIC ACID; K1; SYSTEM; CELLS; POLYSIALYLTRANSFERASE; POLYSIALYLATION;

D O I：

10.1007/s00253-015-7019-x

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Polysialic acid (PSA) is a unique polysaccharide that plays critical roles in many bioprocesses, which makes it useful in a wide range of biomedical applications. The increased demand for PSA has led to considerable efforts to improve its production using bacteria, such as Escherichia coli. Bioprocess optimization and metabolic engineering have allowed the efficient production of PSA. This review aims to summarize the metabolism of PSA with an emphasis on the importance of the key pathway components. In addition, this review provides an update on state of the art PSA production using E. coli with a special emphasis on strategies of strain engineering and process development for the enhanced production of PSA.

引用

页码：1 / 8

页数：8

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