Exploring the link between diabetes and pancreatic cancer

被引：25

作者：

Pizzato, Margherita ^{[1
]}

Turati, Federica ^{[1
]}

Rosato, Valentina ^{[2
]}

La Vecchia, Carlo ^{[1
]}

机构：

[1] Univ Milan, Dept Clin Sci & Community Hlth, Via Vanzetti 5, I-20133 Milan, Italy

[2] Fdn IRCCS Ist Nazl Tumori Milano, Unit Med Stat & Biometry, Milan, Italy

来源：

EXPERT REVIEW OF ANTICANCER THERAPY | 2019年 / 19卷 / 08期

关键词：

Pancreatic cancer; review; type; 2; diabetes; type 3c diabetes; POPULATION-BASED COHORT; POTENTIAL BIOMARKER; INSULIN-RESISTANCE; DETECTION BIAS; BLOOD-GLUCOSE; RISK; MELLITUS; MORTALITY; METAANALYSIS; ASSOCIATION;

D O I：

10.1080/14737140.2019.1642109

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Introduction: Epidemiological studies indicate an association between type 2 diabetes and pancreatic cancer but the complex and multidirectional relationship between them remains unclear. Areas covered: We summarized epidemiological evidence on diabetes and pancreatic cancer exploring the time-risk relationship. We described mechanisms linking long-standing diabetes to pancreatic cancer. We discussed pancreatic cancer-associated diabetes and its implication in the early detection of pancreatic cancer. Expert opinion: The markedly increased risk of pancreatic cancer in patients with new-onset diabetes compared with long-standing diabetes observed in several epidemiological studies indicates a complex and bidirectional connection, with long-standing diabetes being a predisposing factor for pancreatic cancer (increasing the risk of the malignancy 1.5- to 2-fold) and new-onset diabetes an early manifestation of the tumor. Identifying clinical features and biomarkers to distinguish pancreatic cancer-associated diabetes from type 2 diabetes is an important goal to improve management and survival of this cancer. Imaging (MRI) for middle-age patients with new-onset diabetes may be considered.

引用

页码：681 / 687

页数：7

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