Advanced in the Synthesis of Kaurane Diterpenoids

被引：24

作者：

Du, Mingjun ^{[1
]}

Lei, Xiaoguang ^{[1
,2
]}

机构：

[1] Tianjin Univ, Shoool Pharmaceut Sci & Technol, Tianjin 300072, Peoples R China

[2] Peking Univ, Coll Chem & Mol Engn, Beijing 100871, Peoples R China

来源：

CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2015年 / 35卷 / 12期

关键词：

diterpenoids; ent-kaurane; total synthesis; ANTI-AIDS AGENTS; ENANTIOSELECTIVE TOTAL-SYNTHESIS; STEREOSELECTIVE TOTAL-SYNTHESIS; TRIPTERYGIUM-WILFORDII; ANTIBACTERIAL ACTIVITY; ISODON-ERIOCALYX; HIV PRINCIPLE; CONSTRUCTION; ROUTE;

D O I：

10.6023/cjoc201509027

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Kaurane, especially ent-kaurane diterpenoids are integral parts of terpenoid natural products, and possess various bioactivities, including antibacterial, antitumor, antimalarial and antiviral activities. Additionally, as a result of intramolecular oxidations, cleavages and rearrangements, the tetracyclic ent-kaurane also shows attractive structural diversity. Hence, the total syntheses of ent-kauranes have evoked a great deal of interest in the synthetic community. This review presents the recent advances in the synthesis of ent-kaurane and kauranediterpenoids.

引用

页码：2447 / 2464

页数：18

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