Chiral amino alcohols derived from (S)-6-chloronicotine as catalysts for asymmetric synthesis

被引：12

作者：

Capracotta, Sonja S. ^{[1
]}

Comins, Daniel L. ^{[1
]}

机构：

[1] N Carolina State Univ, Dept Chem, Raleigh, NC 27695 USA

来源：

TETRAHEDRON LETTERS | 2009年 / 50卷 / 16期

基金：

美国国家科学基金会;

关键词：

NICOTINIC ACETYLCHOLINE-RECEPTORS; LIGANDS; SUBSTITUTION; DIETHYLZINC;

D O I：

10.1016/j.tetlet.2009.02.012

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Commercially available (S)-nicotine was converted in two or three synthetic steps to various chiral amino alcohols. These nicotine derivatives were evaluated as potential chiral ligands for metal-catalyzed asymmetric reactions by using the addition of diethylzinc to aldehydes as a screen. Several reactions proceeded with a high degree of enantioselectivity providing good yields of secondary alcohols of high enantiopurity. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：1806 / 1808

页数：3

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