Amorphous Calcium Phosphate Formation and Aggregation Process Revealed by Light Scattering Techniques

被引:27
|
作者
Cadez, Vida [1 ]
Erceg, Ina [1 ]
Selmani, Atida [1 ]
Jurasin, Darija Domazet [1 ]
Segota, Suzana [1 ]
Lyons, Daniel M. [2 ]
Kralj, Damir [3 ]
Sikiric, Maja Dutour [1 ]
机构
[1] Ruder Boskovkic Inst, Div Phys Chem, Bijenicka Cesta 54, Zagreb 10000, Croatia
[2] Ruder Boskovkic Inst, Ctr Marine Res, Giordano Pagliaga 5, Rovinj 5210, Croatia
[3] Ruder Boskovkic Inst, Div Mat Chem, Bijenicka Cesta 54, Zagreb 10000, Croatia
来源
CRYSTALS | 2018年 / 8卷 / 06期
关键词
amorphous calcium phosphate; dynamic light scattering; laser diffraction; aggregation; POSNERS CLUSTER; CRYSTALLIZATION; HYDROXYAPATITE; NUCLEATION; KINETICS; BONE; TRANSFORMATION; PRECIPITATION; PHASE; BIOMINERALIZATION;
D O I
10.3390/cryst8060254
中图分类号
O7 [晶体学];
学科分类号
0702 ; 070205 ; 0703 ; 080501 ;
摘要
Amorphous calcium phosphate (ACP) attracts attention as a precursor of crystalline calcium phosphates (CaPs) formation in vitro and in vivo as well as due to its excellent biological properties. Its formation can be considered to be an aggregation process. Although aggregation of ACP is of interest for both gaining a fundamental understanding of biominerals formation and in the synthesis of novel materials, it has still not been investigated in detail. In this work, the ACP aggregation was followed by two widely applied techniques suitable for following nanoparticles aggregation in general: dynamic light scattering (DLS) and laser diffraction (LD). In addition, the ACP formation was followed by potentiometric measurements and formed precipitates were characterized by Fourier transform infrared spectroscopy (FTIR), powder X-ray diffraction (PXRD), transmission electron microscopy (TEM), and atomic force microscopy (AFM). The results showed that aggregation of ACP particles is a process which from the earliest stages simultaneously takes place at wide length scales, from nanometers to micrometers, leading to a highly polydisperse precipitation system, with polydispersity and vol. % of larger aggregates increasing with concentration. Obtained results provide insight into developing a way of regulating ACP and consequently CaP formation by controlling aggregation on the scale of interest.
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页数:14
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