Pathology, Molecular Biology, and Prognosis of Penile Squamous Cell Carcinoma: What Can We Learn from the Specimen?

被引：0
|
作者：
Hakenberg, Oliver W. [1 ]
Draeger, Desiree [1 ]
Erbersdobler, Andreas [2 ]
机构：
[1] Univ Med Rostock, Klin & Poliklin Urol, Schillingallee 35, D-18057 Rostock, Germany
[2] Univ Med Rostock, Inst Pathol, Rostock, Germany
来源：
EUROPEAN UROLOGY SUPPLEMENTS | 2018年 / 17卷 / 06期
关键词：
Penile cancer; Squamous cell carcinoma; Prognosis; Molecular carcinogenesis; Biomarkers; Histology; HUMAN-PAPILLOMAVIRUS; P16(INK4A) EXPRESSION; GENE-MUTATIONS; CANCER; METASTASIS; SURVIVAL; LYMPHADENECTOMY; IDENTIFICATION; OPPORTUNITIES; CHEMOTHERAPY;
D O I：
10.1016/j.eursup.2018.05.004
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
In the treatment of penile cancer, there is a need for prognostic and predictive factors allowing assessment of the likelihood of lymph node metastasis, as this would greatly facilitate clinical decision-making for invasive staging of inguinal nodes. Furthermore, systemic chemotherapy in metastatic disease has limited efficacy and more effective additional or second-line therapies are needed. There is a great interest in personalised and targeted therapies at present, but do we have any indications that these will be useful in penile cancer? This review examines the well-proven predictors of prognosis that pathologists can take from specimens, and reports which molecular markers are of proven value in penile cancer. (C) 2018 European Association of Urology. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：138 / 145
页数：8
相关论文
共 50 条
  • [41] Molecular subtypes based on DNA methylation predict prognosis in lung squamous cell carcinoma
    Li, Xiu-Shen
    Nie, Ke-Chao
    Zheng, Zhi-Hua
    Zhou, Rui-Sheng
    Huang, Yu-Sheng
    Ye, Zeng-Jie
    He, Fan
    Tang, Ying
    BMC CANCER, 2021, 21 (01)
  • [42] Application of hepatocellular carcinoma surveillance in a European setting. What can we learn from clinical practice?
    Edenvik, Pia
    Davidsdottir, Loa
    Oksanen, Antti
    Isaksson, Bengt
    Hultcrantz, Rolf
    Stal, Per
    LIVER INTERNATIONAL, 2015, 35 (07) : 1862 - 1871
  • [43] Renal cell carcinoma: from pathology to molecular neoplastic processes
    Perrin, C.
    Edeline, J.
    Vigneau, C.
    Patard, J. -J.
    Rioux-Leclercq, N.
    ONCOLOGIE, 2009, 11 (05) : 254 - 259
  • [44] Hypermethylation of the thrombospondin-1 gene is associated with poor prognosis in penile squamous cell carcinoma
    Guerrero, David
    Guarch, Rosa
    Ojer, Amaya
    Casas, Juan Manuel
    Ropero, Santiago
    Mancha, Ana
    Pesce, Carlo
    Lloveras, Belen
    Garcia-Bragado, Federico
    Puras, Ana
    BJU INTERNATIONAL, 2008, 102 (06) : 747 - 755
  • [45] Keratoacanthoma and squamous cell carcinoma are distinct from a molecular perspective
    Ra, Seong H.
    Su, Albert
    Li, Xinmin
    Zhou, Jaime
    Cochran, Alistair J.
    Kulkarni, Rajan P.
    Binder, Scott W.
    MODERN PATHOLOGY, 2015, 28 (06) : 799 - 806
  • [46] Ovarian Clear Cell Carcinoma: From Morphology to Molecular Biology
    Improta, Giuseppina
    Pettinato, Angela
    Hogdall, Estrid
    Santeusanio, Giuseppe
    Vatrano, Simona
    Fraggetta, Filippo
    Zannoni, Gian Franco
    APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY, 2019, 27 (09) : 631 - 636
  • [47] Molecular targets for anticancer therapies in companion animals and humans: what can we learn from each other?
    Hernandez, Irati Beltran
    Kromhout, Jannes Z.
    Teske, Erik
    Hennink, Wim E.
    van Nimwegen, Sebastiaan A.
    Oliveira, Sabrina
    THERANOSTICS, 2021, 11 (08): : 3882 - 3897
  • [48] Human Papillomavirus Type 16 DNA Detected in Pulmonary Metastases From a Penile Squamous Cell Carcinoma: A Case Study
    Lorenzon, Laura
    Benevolo, Maria
    Visca, Paolo
    Venturo, Irene
    Filippetti, Massimo
    Piro, Francesca Romana
    Rollo, Francesca
    Vocaturo, Amina
    INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY, 2013, 21 (01) : 59 - 62
  • [49] Histopathological image and gene expression pattern analysis for predicting molecular features and prognosis of head and neck squamous cell carcinoma
    Chen, Linyan
    Zeng, Hao
    Zhang, Mingxuan
    Luo, Yuling
    Ma, Xuelei
    CANCER MEDICINE, 2021, 10 (13): : 4615 - 4628
  • [50] What can we learn from epidemiological studies on chronic boron exposure?
    Duydu, Yalcin
    Basaran, Nursen
    Bolt, Hermann M.
    CRITICAL REVIEWS IN TOXICOLOGY, 2023, 53 (03) : 168 - 180
12345