Molecular Approaches for Diagnosis, Therapy and Prevention of Cow's Milk Allergy

被引：42

作者：

Linhart, Birgit ^{[1
]}

Freidl, Raphaela ^{[1
]}

Elisyutina, Olga ^{[2
]}

Khaitov, Musa ^{[2
]}

Karaulov, Alexander ^{[3
]}

Valenta, Rudolf ^{[1
,2
,3
]}

机构：

[1] Med Univ Vienna, Dept Pathophysiol & Allergy Res, A-1090 Vienna, Austria

[2] NRC Inst Immunol FMBA Russia, Moscow 115478, Russia

[3] Sechenov First Moscow State Med Univ, Dept Clin Immunol & Allergy, Lab Immunopathol, Moscow 119435, Russia

来源：

NUTRIENTS | 2019年 / 11卷 / 07期

基金：

奥地利科学基金会;

关键词：

cow's milk allergy; cow's milk allergens; diagnosis of cow's milk allergy; molecular diagnosis; treatment of cow's milk allergy; prevention of cow's milk allergy; ATOPY PATCH TEST; SKIN PRICK TEST; INFANT NUTRITIONAL INTERVENTION; ORAL IMMUNOTHERAPY; PREDICTIVE-VALUE; FOOD ALLERGY; EPICUTANEOUS IMMUNOTHERAPY; DOUBLE-BLIND; BETA-LACTOGLOBULIN; IGE REACTIVITY;

D O I：

10.3390/nu11071492

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Cow's milk is one of the most important and basic nutrients introduced early in life in our diet but can induce IgE-associated allergy. IgE-associated allergy to cow's milk can cause severe allergic manifestations in the gut, skin and even in the respiratory tract and may lead to life-threatening anaphylactic shock due to the stability of certain cow's milk allergens. Here, we provide an overview about the allergen molecules in cow's milk and the advantages of the molecular diagnosis of IgE sensitization to cow's milk by serology. In addition, we review current strategies for prevention and treatment of cow's milk allergy and discuss how they could be improved in the future by innovative molecular approaches that are based on defined recombinant allergens, recombinant hypoallergenic allergen derivatives and synthetic peptides.

引用

页数：24

共 175 条

[1] Kounis syndrome: A review article on epidemiology, diagnostic findings, management and complications of allergic acute coronary syndrome [J].

Abdelghany, Mahmoud ;

Subedi, Rogin ;

Shah, Siddharth ;

Kozman, Hani .

INTERNATIONAL JOURNAL OF CARDIOLOGY, 2017, 232 :1-4

[2] Interference in immunoassays by human IgM with specificity for the carbohydrate moiety of animal proteins [J].

Adédoyin, J ;

Johansson, SGO ;

Grönlund, H ;

van Hage, M .

JOURNAL OF IMMUNOLOGICAL METHODS, 2006, 310 (1-2) :117-125

[3] Cat IgA, representative of new carbohydrate cross-reactive allergens [J].

Adedoyin, Justus ;

Gronlund, Hans ;

Oman, Hans ;

Johansson, S. G. O. ;

van Hage, Marianne .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2007, 119 (03) :640-645

[4] Individual cow's milk allergens as prognostic markers for tolerance development? [J].

Ahrens, B. ;

de Oliveira, L. C. Lopes ;

Grabenhenrich, L. ;

Schulz, G. ;

Niggemann, B. ;

Wahn, U. ;

Beyer, K. .

CLINICAL AND EXPERIMENTAL ALLERGY, 2012, 42 (11) :1630-1637

[5] Partially Hydrolyzed 100% Whey Protein Infant Formula and Reduced Risk of Atopic Dermatitis: A Meta-analysis [J].

Alexander, Dominik D. ;

Cabana, Michael D. .

JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, 2010, 50 (04) :422-430

[6] Is a slow-progression baked milk protocol of oral immunotherapy always a safe option for children with cow's milk allergy? A randomized controlled trial [J].

Amat, F. ;

Kouche, C. ;

Gaspard, W. ;

Lemoine, A. ;

Guiddir, T. ;

Lambert, N. ;

Zakariya, M. ;

Ridray, C. ;

Nemni, A. ;

Saint-Pierre, P. ;

Deschildre, A. ;

Couderc, R. ;

Just, J. .

CLINICAL AND EXPERIMENTAL ALLERGY, 2017, 47 (11) :1491-1496

[7] Mechanisms of the Development of Allergy (MeDALL): Introducing novel concepts in allergy phenotypes [J].

Anto, Josep M. ;

Bousquet, Jean ;

Akdis, Mubeccel ;

Auffray, Charles ;

Keil, Thomas ;

Momas, Isabelle ;

Postma, Dirkje S. ;

Valenta, Rudolf ;

Wickman, Magnus ;

Cambon-Thomsen, Anne ;

Haahtela, Tari ;

Lambrecht, Bart N. ;

Carlsen, Karin C. Lodrup ;

Koppelman, Gerard H. ;

Sunyer, Jordi ;

Zuberbier, Torsten ;

Annesi-Maesano, Isabelle ;

Arno, Albert ;

Bindslev-Jensen, Carsten ;

De Carlo, Giuseppe ;

Forastiere, Francesco ;

Heinrich, Joachim ;

Kowalski, Marek L. ;

Maier, Dieter ;

Melen, Erik ;

Smit, Henriette A. ;

Standl, Marie ;

Wright, John ;

Asarnoj, Anna ;

Benet, Marta ;

Ballardini, Natalia ;

Garcia-Aymerich, Judith ;

Gehring, Ulrike ;

Guerra, Stefano ;

Hohmann, Cynthia ;

Kull, Inger ;

Lupinek, Christian ;

Pinart, Mariona ;

Skrindo, Ingebjorg ;

Westman, Marit ;

Smagghe, Delphine ;

Akdis, Cezmi ;

Andersson, Niklas ;

Bachert, Claus ;

Ballereau, Stephane ;

Ballester, Ferran ;

Basagana, Xavier ;

Bedbrook, Anna ;

Bergstrom, Anna ;

von Berg, Andrea .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2017, 139 (02) :388-399

[8] Sensitization to cat and dog allergen molecules in childhood and prediction of symptoms of cat and dog allergy in adolescence: ABAMSE/MeDALL study [J].

Asarnoj, Anna ;

Hamsten, Carl ;

Waden, Konrad ;

Lupinek, Christian ;

Andersson, Niklas ;

Kull, Inger ;

Curin, Mirela ;

Anto, Josep ;

Bousquet, Jean ;

Valenta, Rudolf ;

Wickman, Magnus ;

van Hage, Marianne .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2016, 137 (03) :813-+

[9] Tolerability and palatability of donkey's milk in children with cow's milk allergy [J].

Barni, Simona ;

Sarti, Lucrezia ;

Mori, Francesca ;

Muscas, Giada ;

Belli, Fina ;

Pucci, Neri ;

Novembre, Elio .

PEDIATRIC ALLERGY AND IMMUNOLOGY, 2018, 29 (03) :329-331

[10] Early oral immunotherapy in infants with cow's milk protein allergy [J].

Berti, Irene ;

Badina, Laura ;

Cozzi, Giorgio ;

Giangreco, Manuela ;

Bibalo, Cristina ;

Ronfani, Luca ;

Barbi, Egidio ;

Ventura, Alessandro ;

Longo, Giorgio .

PEDIATRIC ALLERGY AND IMMUNOLOGY, 2019, 30 (05) :572-574

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