Vulvar plasmablastic lymphoma in a HIV-positive child: a novel extraoral localisation

被引：21

作者：

Chabay, P. ^{[1
]}

De Matteo, E.

Lorenzetti, M. ^{[1
]}

Gutierrez, M. ^{[2
]}

Narbaitz, M. ^{[3
]}

Aversa, L. ^{[2
]}

Preciado, M. V. ^{[1
]}

机构：

[1] Hosp Ninos Dr Ricardo Gutierrez, Mol Biol Lab, Div Patol, Buenos Aires, DF, Argentina

[2] Hosp Ninos Dr Ricardo Gutierrez, Hematol Unit, Buenos Aires, DF, Argentina

[3] Natl Acad Med Buenos Aires, Mariano R Castex Hematol Res Inst, Buenos Aires, DF, Argentina

来源：

JOURNAL OF CLINICAL PATHOLOGY | 2009年 / 62卷 / 07期

关键词：

ORAL-CAVITY; ENTITIES;

D O I：

10.1136/jcp.2009.064758

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Plasmablastic lymphoma (PBL) has been characterised by the World Health Organization as a new entity. This report describes an unusual case of PBL in a 3-year-old HIV-infected patient showing a cutaneous vulvar lesion with 9 months of evolution and prolapsed vulvovaginal mucosa. Histopathological examination of a biopsy sample showed diffuse submucosal infiltration by large cells with a cohesive growth pattern, and round and vesicular nuclei with fine chromatin centrally or eccentrically placed with one or more prominent nucleoli. Immunohistochemical staining in neoplastic cells was positive for multiple melanoma oncogene (MUM1), CD138, CD45 and epithelial membrane antigen (EMA). The diagnosis was PBL, stage III. Epstein-Barr virus (EBV) expression was positive by EBV encoded RNAs in situ hybridisation. This is believed to be the third case of paediatric HIV-associated PBL reported in the literature, and the first with vulvar localisation, which is a new anatomical location for this entity.

引用

页码：644 / 646

页数：3

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