Nonhuman Primate Models of Neuropsychiatric Disorders: Influences of Early Rearing, Genetics, and Epigenetics

被引：25

作者：

Dettmer, Amanda M. ^{[1
]}

Suomi, Stephen J. ^{[2
]}

机构：

[1] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, LCE, NIH, Poolesville, MD 20837 USA

[2] LCE, Bethesda, MD USA

来源：

ILAR JOURNAL | 2014年 / 55卷 / 02期

关键词：

early life adversity; epigenetics; genetics; neuropsychiatric disorders; nonhuman primate; rhesus macaque; EXCESSIVE ALCOHOL-CONSUMPTION; LINKED POLYMORPHIC REGION; CSF MONOAMINE METABOLITE; TOTAL SOCIAL-ISOLATION; SEROTONIN TRANSPORTER; RHESUS MACAQUES; ENVIRONMENT INTERACTIONS; PLASMA-CORTISOL; BEHAVIORAL-INHIBITION; MATERNAL SEPARATION;

D O I：

10.1093/ilar/ilu025

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

This report reviews the scientific literature from the past several decades that focuses on nonhuman primates (NHPs) as models of neuropsychiatric disorders, including anxiety, and alcoholism. In particular, we highlight the approaches, advantages, and disadvantages of the rearing, genetic, and epigenetic methodologies behind these studies as a means of evaluating the application of these methods in assessing disorders in NHPs as models of human disease. Finally, we describe the contributions the NHP studies have made to neuropsychiatric research and areas for future research.

引用

页码：361 / 370

页数：10

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