Second cancer risk after 3D-CRT, IMRT and VMAT for breast cancer

被引：129

作者：

Abo-Madyan, Yasser ^{[1
,2
]}

Aziz, Muhammad Hammad ^{[1
,3
]}

Aly, Moamen M. O. M. ^{[4
,5
]}

Schneider, Frank ^{[1
]}

Sperk, Elena ^{[1
]}

Clausen, Sven ^{[1
]}

Giordano, Frank A. ^{[1
]}

Herskind, Carsten ^{[1
]}

Steil, Volker ^{[1
]}

Wenz, Frederik ^{[1
]}

Glatting, Gerhard ^{[1
,4
]}

机构：

[1] Heidelberg Univ, Univ Med Mannheim, Med Fak Mannheim, Dept Radiat Oncol, D-68167 Mannheim, Germany

[2] Cairo Univ, Fac Med, Dept Radiat Oncol & Nucl Med NEMROCK, Giza, Egypt

[3] COMSATS Inst Informat & Technol, Dept Phys, Islamabad, Pakistan

[4] Heidelberg Univ, Univ Med Mannheim, Med Fak Mannheim, D-68167 Mannheim, Germany

[5] Assiut Univ, South Egypt Canc Inst, Dept Radiotherapy & Nucl Med, Assiut, Egypt

来源：

RADIOTHERAPY AND ONCOLOGY | 2014年 / 110卷 / 03期

关键词：

Second cancer risk; Organ equivalent dose (OED); Breast cancer; Intensity modulated radiation therapy (IMRT); MODULATED RADIATION-THERAPY; MONTE-CARLO; CONTRALATERAL BREAST; ADJUVANT RADIOTHERAPY; RANDOMIZED-TRIAL; SURVIVORS; EFFICACY;

D O I：

10.1016/j.radonc.2013.12.002

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Purpose: Second cancer risk after breast conserving therapy is becoming more important due to improved long term survival rates. In this study, we estimate the risks for developing a solid second cancer after radiotherapy of breast cancer using the concept of organ equivalent dose (OED). Materials and methods: Computer-tomography scans of 10 representative breast cancer patients were selected for this study. Three-dimensional conformal radiotherapy (3D-CRT), tangential intensity modulated radiotherapy (t-IMRT), multibeam intensity modulated radiotherapy (m-IMRT), and volumetric modulated arc therapy (VMAT) were planned to deliver a total dose of 50 Gy in 2 Gy fractions. Differential dose volume histograms (dDVHs) were created and the OEDs calculated. Second cancer risks of ipsilateral, contralateral lung and contralateral breast cancer were estimated using linear, linear-exponential and plateau models for second cancer risk. Results: Compared to 3D-CRT, cumulative excess absolute risks (EAR) for t-IMRT, m-IMRT and VMAT were increased by 2 +/- 15%, 131 +/- 85%, 123 +/- 66% for the linear-exponential risk model, 9 +/- 22%, 82 +/- 96%, 71 +/- 82% for the linear and 3 +/- 14%, 123 +/- 78%, 113 +/- 61% for the plateau model, respectively. Conclusion: Second cancer risk after 3D-CRT or t-IMRT is lower than for m-IMRT or VMAT by about 34% for the linear model and 50% for the linear-exponential and plateau models, respectively. (C) 2013 Elsevier Ireland Ltd. All rights reserved.

引用

页码：471 / 476

页数：6

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