The regulation of INK4/ARF in cancer and aging

被引：809
作者：
Kim, William Y.
Sharpless, Norman E. [1 ]
机构：
[1] Univ N Carolina, Sch Med, Dept Med, Chapel Hill, NC 27599 USA
[2] Univ N Carolina, Sch Med, Dept Genet, Chapel Hill, NC 27599 USA
来源：
CELL | 2006年 / 127卷 / 02期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1016/j.cell.2006.10.003
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Loss of the INK4a/ARF/INK4b locus on chromosome 9p21 is among the most frequent cytogenetic events in human cancer. The products of the locus-p15(INK4b), p(16INK4a), and ARF-play widespread and independent roles in tumor suppression. Recent data also suggest that expression of p(16INK4a) induces an age-dependent decrease in the proliferative capacity of certain tissue-specific stem cells and unipotent progenitors. Here, we discuss the regulation and role of p(16INK4a), ARF, and p(15INK4b) in cancer and aging.
引用
收藏
页码：265 / 275
页数：11
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