The adipose renin-angiotensin system: Role in cardiovascular disease

被引：85

作者：

Thatcher, Sean ^{[1
]}

Yiannikouris, Frederique ^{[1
]}

Gupte, Manisha ^{[1
]}

Cassis, Lisa ^{[1
]}

机构：

[1] Univ Kentucky, Grad Ctr Nutr Sci, Lexington, KY 40536 USA

来源：

MOLECULAR AND CELLULAR ENDOCRINOLOGY | 2009年 / 302卷 / 02期

关键词：

Angiotensin; Adipocyte; Renin-angiotensin system; INCREASED ENERGY-EXPENDITURE; DIET-INDUCED OBESITY; GENE-EXPRESSION; II RECEPTORS; VASCULAR FUNCTION; MESSENGER-RNA; HUMAN PREADIPOCYTES; HUMAN ADIPOCYTES; TISSUE; SECRETION;

D O I：

10.1016/j.mce.2009.01.019

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Several reviews have highlighted the importance of local tissue production of components of the renin-angiotensin system (RAS) [Bader, M., Ganten, D., 2008. Update on tissue renin-angiotensin systems. J. Mol. Med. 86, 615-621; Krop, M., Danser, A.H., 2008. Circulating versus tissue renin-angiotensin system: on the origin of (pro)renin. Curr. Hypertens. Rep. 10, 112-118; Paul, M., Poyan Mehr, A., Kreutz, R., 2006. Physiology of local renin-angiotensin systems. Physiol. Rev. 86, 747-803]. While the concept of tissue RAS is gaining more widespread acceptance, the concept of local angiotensin II (AngII) production, acting in coordinate or independently of the endocrine RAS, continues to be debated. The primary reasons that local AngII production has been studied by many investigators are that components of the RAS are expressed by multiple cell types, and that the endocrine RAS cannot fully explain all effects of AngII. Moreover, through the development and study of genetically altered models for over-expression or knockdown of individual RAS components within specific cell types, it is becoming increasingly more evident that local RAS contribute to effects of AngII in normal physiology and disease. The purpose of this review is to define the presence and physiological significance of a local RAS in adipose tissue in relation to cardiovascular disease. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

引用

页码：111 / 117

页数：7

共 78 条

[11] Fat cell metabolism: Insulin, fatty acids, and renin [J].

Cassis L.A. .

Current Hypertension Reports, 2000, 2 (2) :132-138

[12]

Cassis LA, 1996, ADV EXP MED BIOL, V396, P39

[13] ANGIOTENSIN-II IN BROWN ADIPOSE-TISSUE FROM YOUNG AND ADULT ZUCKER OBESE AND LEAN RATS [J].

CASSIS, LA .

AMERICAN JOURNAL OF PHYSIOLOGY, 1994, 266 (03) :E453-E458

[14] DOWN-REGULATION OF THE RENIN-ANGIOTENSIN SYSTEM IN STREPTOZOTOCIN-DIABETIC RATS [J].

CASSIS, LA .

AMERICAN JOURNAL OF PHYSIOLOGY, 1992, 262 (01) :E105-E109

[15] LOCATION AND REGULATION OF RAT ANGIOTENSINOGEN MESSENGER-RNA [J].

CASSIS, LA ;

SAYE, J ;

PEACH, MJ .

HYPERTENSION, 1988, 11 (06) :591-596

[16] LOCALIZATION OF ANGIOTENSINOGEN MESSENGER-RNA IN RAT AORTA [J].

CASSIS, LA ;

LYNCH, KR ;

PEACH, MJ .

CIRCULATION RESEARCH, 1988, 62 (06) :1259-1262

[17] Angiotensin II receptors in human preadipocytes: Role in cell cycle regulation [J].

Crandall, DL ;

Armellino, DC ;

Busler, DE ;

McHendry-Rinde, B ;

Kral, JG .

ENDOCRINOLOGY, 1999, 140 (01) :154-158

[18]

CRANDALL DL, 1994, J LIPID RES, V35, P1378

[19]

DARIMONT C, 1994, INT J OBESITY, V18, P783

[20] Differences in mRNA expression of the proteins secreted by the adipocytes in human subcutaneous and visceral adipose tissues [J].

Dusserre, E ;

Moulin, P ;

Vidal, H .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 2000, 1500 (01) :88-96

← 1 2 3 4 5 6 7 8 →