High-performance polarization control modulated surface plasmon resonance sensor based on monolayer graphene/Au-NPs architecture for detection of DNA hybridization

被引：5

作者：

Sun, Yi ^{[1
,2
]}

Cai, Haoyuan ^{[1
,2
]}

Qiao, Xin ^{[1
,2
]}

Wang, Xiaoping ^{[1
,2
,3
]}

机构：

[1] Zhejiang Univ, Ocean Coll, Zhoushan 316021, Peoples R China

[2] Zhejiang Univ, Key Lab Ocean Observat Imaging Testbed Zhejiang P, Zhoushan 316021, Peoples R China

[3] Zhejiang Univ, Coll Opt Sci & Engn, State Key Lab Modern Opt Instrumentat, Hangzhou 310027, Zhejiang, Peoples R China

来源：

MEASUREMENT SCIENCE AND TECHNOLOGY | 2019年 / 30卷 / 12期

基金：

中国国家自然科学基金;

关键词：

plasmonic biosensor; DNA hybridization; graphene; Au nanoparticles; surface plasmon resonance; COLORIMETRIC DETECTION; NANOPARTICLES; OXIDE; BIOSENSOR; PLATFORM; CARBON;

D O I：

10.1088/1361-6501/ab383a

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

A highly sensitive polarization control modulated plasmonic biosensor based on monolayer graphene/Au-NPs for direct detection of single-stranded DNA (ssDNA) hybridization is reported. The presence of monolayer graphene on gold film provides novel functionalized derivatives through pi-stacking interactions. In addition, the online assembly strategy via in situ monitoring between ssDNA and Au-NPs makes the binding easier and quantifiable. The use of strong plasmon-mediated energy confinements induces an approximately 30-fold intense field enhancement of the reflected light. The architecture exhibits a linear dynamic range of 10(-15) to 10(-7) M for the detection of target ssDNA. Moreover, the new biosensor can achieve an ultralow detection limit of 500 aM for 23-mer ssDNA via improved sensitivity to molecular bindings.

引用

页数：9

共 43 条

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