High-performance polarization control modulated surface plasmon resonance sensor based on monolayer graphene/Au-NPs architecture for detection of DNA hybridization

被引：5
|
作者：
Sun, Yi [1 ,2 ]
Cai, Haoyuan [1 ,2 ]
Qiao, Xin [1 ,2 ]
Wang, Xiaoping [1 ,2 ,3 ]
机构：
[1] Zhejiang Univ, Ocean Coll, Zhoushan 316021, Peoples R China
[2] Zhejiang Univ, Key Lab Ocean Observat Imaging Testbed Zhejiang P, Zhoushan 316021, Peoples R China
[3] Zhejiang Univ, Coll Opt Sci & Engn, State Key Lab Modern Opt Instrumentat, Hangzhou 310027, Zhejiang, Peoples R China
来源：
MEASUREMENT SCIENCE AND TECHNOLOGY | 2019年 / 30卷 / 12期
基金：
中国国家自然科学基金;
关键词：
plasmonic biosensor; DNA hybridization; graphene; Au nanoparticles; surface plasmon resonance; COLORIMETRIC DETECTION; NANOPARTICLES; OXIDE; BIOSENSOR; PLATFORM; CARBON;
D O I：
10.1088/1361-6501/ab383a
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
A highly sensitive polarization control modulated plasmonic biosensor based on monolayer graphene/Au-NPs for direct detection of single-stranded DNA (ssDNA) hybridization is reported. The presence of monolayer graphene on gold film provides novel functionalized derivatives through pi-stacking interactions. In addition, the online assembly strategy via in situ monitoring between ssDNA and Au-NPs makes the binding easier and quantifiable. The use of strong plasmon-mediated energy confinements induces an approximately 30-fold intense field enhancement of the reflected light. The architecture exhibits a linear dynamic range of 10(-15) to 10(-7) M for the detection of target ssDNA. Moreover, the new biosensor can achieve an ultralow detection limit of 500 aM for 23-mer ssDNA via improved sensitivity to molecular bindings.
引用
收藏
页数：9
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