Crosstalk between long non-coding RNA DLX6-AS1, microRNAs and signaling pathways: A pivotal molecular mechanism in human cancers

被引：14

作者：

Alizadeh, Anita ^{[1
]}

Jebelli, Asiyeh ^{[1
]}

Baradaran, Behzad ^{[2
]}

Amini, Mohammad ^{[2
]}

Oroojalian, Fatemeh ^{[3
]}

Hashemzaei, Mahmoud ^{[4
]}

Mokhtarzadeh, Ahad ^{[2
]}

Hamblin, Michael R. ^{[5
,6
]}

机构：

[1] Higher Educ Inst Rab Rashid, Fac Basic Sci, Dept Biol Sci, Tabriz, Iran

[2] Tabriz Univ Med Sci, Immunol Res Ctr, Tabriz, Iran

[3] North Khorasan Univ Med Sci, Dept Adv Sci & Technol, Bojnurd, Iran

[4] Zabol Univ Med Sci, Sch Pharm, Dept Pharmacodynam & Aptameol, Zabol, Iran

[5] Harvard Med Sch, Massachusetts Gen Hosp, Wellman Ctr Photomed, Boston, MA 02114 USA

[6] Univ Johannesburg, Fac Hlth Sci, Laser Res Ctr, ZA-2028 Doornfontein, South Africa

来源：

GENE | 2021年 / 769卷

关键词：

LncRNA; DLX6-AS1; miRNA; Cancer; Therapeutic target; Diagnostic biomarker; EPITHELIAL-MESENCHYMAL TRANSITION; INHIBITS CELL-PROLIFERATION; COMPETING ENDOGENOUS RNA; LNCRNA DLX6-AS1; OVARIAN-CANCER; PROMOTES APOPTOSIS; INVASION; EPIDEMIOLOGY; MIGRATION; PROGRESSION;

D O I：

10.1016/j.gene.2020.145224

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Long non-coding RNAs (lncRNAs) are a type of non-protein coding RNA, which have been found to play multiple roles in various molecular and cellular processes by epigenetic regulation of gene expression at post transcriptional levels. LncRNAs may act either as an oncogene or as a tumor suppressor gene in different cancers. Aberrant expression and dysregulation of lncRNAs has been correlated with cancer development and tumor growth via several different signaling pathways. Therefore, lncRNAs could serve as diagnostic biomarkers and as therapeutic targetes in many human cancers. Previous studies have reported that dysregulated expression of the lncRNA called DLX6-AS1 in various cancer types, such as lung, colorectal, bladder, ovarian, hepatocellular, pancreatic and gastric. DLX6-AS1 plays an important role in tumorigenesis by affecting cell proliferation, migration, invasion, EMT, and apoptosis. DLX6-AS1 exerts these regulatory effects by interfering with various microRNA axes and signaling pathways including, Wnt/beta catenin, Notch, P13/AKT/mTOR, and STAT3. This review focuses on the possible mechanisms by which DLX6-AS1 regulates tumor initiation and progression. Accordingly, DLX6-AS1 may act as a novel potential biomarker for cancer diagnosis or therapy in future.

引用

页数：12

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