Automated identification of basal cell carcinoma by polarization-sensitive optical coherence tomography

被引：29

作者：

Duan, Lian ^{[1
,2
]}

Marvdashti, Tahereh ^{[1
,2
]}

Lee, Alex ^{[3
]}

Tang, Jean Y. ^{[3
]}

Ellerbee, Audrey K. ^{[1
,2
]}

机构：

[1] Stanford Univ, EL Ginzton Lab, Stanford, CA 94305 USA

[2] Stanford Univ, Dept Elect Engn, Stanford, CA 94305 USA

[3] Stanford Univ, Dept Dermatol, Stanford, CA 94305 USA

来源：

BIOMEDICAL OPTICS EXPRESS | 2014年 / 5卷 / 10期

关键词：

NONMELANOMA SKIN-CANCER; UNITED-STATES; BIREFRINGENCE CHARACTERIZATION; CLINICAL-DIAGNOSIS; RAMAN-SPECTROSCOPY; CROSS-VALIDATION; TISSUE; LIGHT; ACCURACY; MELANOMA;

D O I：

10.1364/BOE.5.003717

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

We report an automated classifier to detect the presence of basal cell carcinoma in images of mouse skin tissue samples acquired by polarization-sensitive optical coherence tomography (PS-OCT). The sensitivity and specificity of the classifier based on combined information of the scattering intensity and birefringence properties of the samples are significantly higher than when intensity or birefringence information are used alone. The combined information offers a sensitivity of 94.4% and specificity of 92.5%, compared to 78.2% and 82.2% for intensity-only information and 85.5% and 87.9% for birefringence-only information. These results demonstrate that analysis of the combination of complementary optical information obtained by PS-OCT has great potential for accurate skin cancer diagnosis. (C) 2014 Optical Society of America

引用

页码：3717 / 3729

页数：13

共 35 条

[1] Multi-modal approach using Raman spectroscopy and optical coherence tomography for the discrimination of colonic adenocarcinoma from normal colon [J].

Ashok, Praveen C. ;

Praveen, Bavishna B. ;

Bellini, Nicola ;

Riches, Andrew ;

Dholakia, Kishan ;

Herrington, C. Simon .

BIOMEDICAL OPTICS EXPRESS, 2013, 4 (10) :2179-2186

[2] Development and calibration of an automated Mueller matrix polarization imaging system [J].

Baba, JS ;

Chung, JR ;

DeLaughter, AH ;

Cameron, BD ;

Coté, GL .

JOURNAL OF BIOMEDICAL OPTICS, 2002, 7 (03) :341-349

[3] Efficient leave-one-out cross-validation of kernel Fisher discriminant classifiers [J].

Cawley, GC ;

Talbot, NLC .

PATTERN RECOGNITION, 2003, 36 (11) :2585-2592

[4] The accuracy of clinical diagnosis of suspected premalignant and malignant skin lesions in renal transplant recipients [J].

Cooper, SM ;

Wojnarowska, F .

CLINICAL AND EXPERIMENTAL DERMATOLOGY, 2002, 27 (06) :436-438

[5] Imaging thermally damaged tissue by polarization sensitive optical coherence tomography [J].

de Boer, JF ;

Srinivas, SM ;

Malekafzali, A ;

Chen, ZP ;

Nelson, JS .

OPTICS EXPRESS, 1998, 3 (06) :212-218

[6] Determination of the depth-resolved Stokes parameters of light backscattered from turbid media by use of polarization-sensitive optical coherence tomography [J].

de Boer, JF ;

Milner, TE ;

Nelson, JS .

OPTICS LETTERS, 1999, 24 (05) :300-302

[7] Automated phase retardation oriented segmentation of chorio-scleral interface by polarization sensitive optical coherence tomography [J].

Duan, Lian ;

Yamanari, Masahiro ;

Yasuno, Yoshiaki .

OPTICS EXPRESS, 2012, 20 (03) :3353-3366

[8] Monte-Carlo-based phase retardation estimator for polarization sensitive optical coherence tomography [J].

Duan, Lian ;

Makita, Shuichi ;

Yamanari, Masahiro ;

Lim, Yiheng ;

Yasuno, Yoshiaki .

OPTICS EXPRESS, 2011, 19 (17) :16330-16345

[9] Clinical diagnosis of skin tumours: How good are we? [J].

Ek, EW ;

Giorlando, F ;

Su, SY ;

Dieu, T .

ANZ JOURNAL OF SURGERY, 2005, 75 (06) :415-420

[10] Birefringence characterization of biological tissue by use of optical coherence tomography [J].

Everett, MJ ;

Schoenenberger, K ;

Colston, BW ;

Da Silva, LB .

OPTICS LETTERS, 1998, 23 (03) :228-230

← 1 2 3 4 →