Laying in silico pipelines for drug repositioning: a paradigm in ensemble analysis for neurodegenerative diseases

被引：15

作者：

Dovrolis, Nikolas ^{[1
]}

Kolios, George ^{[1
]}

Spyrou, George ^{[2
]}

Maroulakou, Loanna ^{[3
]}

机构：

[1] Democritus Univ Thrace, Pharmacol Lab, Dept Med, Xanthi, Greece

[2] Cyprus Inst Neurol & Genet, Bioinformat ERA Chair, Nicosia, Cyprus

[3] Democritus Univ Thrace, Dept Mol Biol & Genet, Xanthi, Greece

来源：

DRUG DISCOVERY TODAY | 2017年 / 22卷 / 05期

关键词：

GENE-EXPRESSION; ALZHEIMERS-DISEASE; INHIBITOR; PATHWAYS; THERAPY; REGIONS; BETA; POLYPHARMACOLOGY; IDENTIFICATION; SIGNATURES;

D O I：

10.1016/j.drudis.2017.03.009

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

When faced with time-and money-consuming problems, new practices in pharmaceutical R&D arose when trying to alleviate them. Drug repositioning has great promise and when combined with today's computational power and intelligence it becomes more precise and potent. This work showcases current approaches of creating a computational pipeline for drug repositioning, along with an extensive example of how researchers can influence therapeutic approaches and further understanding, through either single or multiple disease studies. This paradigm is based on three neurodegenerative diseases with pathophysiological similarities. It is our goal to provide the readers with all the information needed to enrich their research and note expectations along the way.

引用

页码：805 / 813

页数：9

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