Biosynthesis of cervimycin C, an aromatic polyketide antibiotic bearing an unusual dimethylmalonyl moiety

被引：25

作者：

Herold, K

Xu, ZL

Gollmick, FA

Gräfe, U

Hertweck, C

机构：

[1] Hans Knoll Inst Nat Prod Res, Dept Biostruct Chem, D-07745 Jena, Germany

[2] Hans Knoll Inst Nat Prod Res, Dept Bioorgan Synth, D-07745 Jena, Germany

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2004年 / 2卷 / 17期

关键词：

D O I：

10.1039/b409221j

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Cervimycin C is the major component of an antibiotic complex produced by Streptomyces tendae HKI-179 consisting of a tetracycline-type aglycon, six tridesoxysugars and a rare dimethylmalonyl moiety. The biosynthetic origin of cervimycin was studied by molecular studies and feeding experiments, which reveal that the dimethylmalonate unit is not derived from malonate, but from valine.

引用

收藏

页码：2411 / 2414

页数：4

相关论文

共 21 条

[1] BIOSYNTHESIS OF BENASTATIN-A [J].

AOYAMA, T ;

NAGANAWA, H ;

MURAOKA, Y ;

AOYAGI, T ;

TAKEUCHI, T .

JOURNAL OF ANTIBIOTICS, 1992, 45 (11) :1767-1772

[2] PLASMID CLONING VECTORS FOR THE CONJUGAL TRANSFER OF DNA FROM ESCHERICHIA-COLI TO STREPTOMYCES SPP [J].

BIERMAN, M ;

LOGAN, R ;

OBRIEN, K ;

SENO, ET ;

RAO, RN ;

SCHONER, BE .

GENE, 1992, 116 (01) :43-49

[3] BIOSYNTHETIC-STUDIES ON THE XANTHONE - ANTIBIOTICS LYSOLIPIN-X AND LYSOLIPIN-I [J].

BOCKHOLT, H ;

UDVARNOKI, G ;

ROHR, J ;

MOCEK, U ;

BEALE, JM ;

FLOSS, HG .

JOURNAL OF ORGANIC CHEMISTRY, 1994, 59 (08) :2064-2069

[4] BIOSYNTHETIC ORIGIN OF THE CARBON SKELETON AND OXYGEN-ATOMS OF THE AVERMECTINS [J].

CANE, DE ;

LIANG, TC ;

KAPLAN, L ;

NALLIN, MK ;

SCHULMAN, MD ;

HENSENS, OD ;

DOUGLAS, AW ;

ALBERSSCHONBERG, G .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1983, 105 (12) :4110-4112

[5] A 2ND BRANCHED-CHAIN ALPHA-KETO ACID DEHYDROGENASE GENE-CLUSTER (BKDFGH) FROM STREPTOMYCES-AVERMITILIS - ITS RELATIONSHIP TO AVERMECTIN BIOSYNTHESIS AND THE CONSTRUCTION OF A BKDF MUTANT SUITABLE FOR THE PRODUCTION OF NOVEL ANTIPARASITIC AVERMECTINS [J].

DENOYA, CD ;

FEDECHKO, RW ;

HAFNER, EW ;

MCARTHUR, HAI ;

MORGENSTERN, MR ;

SKINNER, DD ;

STUTZMANENGWALL, K ;

WAX, RG ;

WERNAU, WC .

JOURNAL OF BACTERIOLOGY, 1995, 177 (12) :3504-3511

[6] Studies on the biosynthesis of epothilones:: The biosynthetic origin of the carbon skeleton [J].

Gerth, K ;

Steinmetz, H ;

Höfle, G ;

Reichenbach, H .

JOURNAL OF ANTIBIOTICS, 2000, 53 (12) :1373-1377

[7] Geomicrobiological study of the Grotta dei Cervi, Porto Badisco, Italy [J].

Groth, I ;

Schumann, P ;

Laiz, L ;

Sanchez-Moral, S ;

Cañaveras, JC ;

Saiz-Jimenez, C .

GEOMICROBIOLOGY JOURNAL, 2001, 18 (03) :241-258

[8] BRANCHED-CHAIN FATTY-ACID REQUIREMENT FOR AVERMECTIN PRODUCTION BY A MUTANT OF STREPTOMYCES-AVERMITILIS LACKING BRANCHED-CHAIN 2-OXO ACID DEHYDROGENASE-ACTIVITY [J].

HAFNER, EW ;

HOLLEY, BW ;

HOLDOM, KS ;

LEE, SE ;

WAX, RG ;

BECK, D ;

MCARTHUR, HAI ;

WERNAU, WC .

JOURNAL OF ANTIBIOTICS, 1991, 44 (03) :349-356

[9]

HEROLD K, UNPUB

[10]

HOFLE G, 1983, LIEBIGS ANN CHEM, P835