Attenuation by nicotinamide of the streptozocin induced early hyperglycaemia in fasting rats

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作者：
Wong, KK
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BIOCHEMISTRY AND MOLECULAR BIOLOGY INTERNATIONAL | 1996年 / 40卷 / 03期
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Q5 [生物化学]; Q7 [分子生物学];
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071010 ; 081704 ;
摘要：
The effect of nicotinamide on the streptozocin induced early hyperglycaemia in 48-hour fasted rats was investigated. It was shown that 240 or 400 mg/kg nicotinamide significantly attenuated the streptozocin induced early hyperglycamia. Nictoinamide should be administrated no later than 1 hour after the streptozocin adm administration. Lower level does of nicotinamide such as 80mg/kg were unable to attenuate the streptozocin induced early hyperglycamia. The possibility of nicotinamide offsetting the streptozocin.
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页码：515 / 520
页数：6
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