Instantaneous Deprotection of Tosylamides and Esters with SmI2/Amine/Water

被引：156

作者：

Ankner, Tobias ^{[1
]}

Hilmersson, Goeran ^{[1
]}

机构：

[1] Univ Gothenburg, Dept Chem, SE-41296 Gothenburg, Sweden

来源：

ORGANIC LETTERS | 2009年 / 11卷 / 03期

关键词：

ASYMMETRIC ADDITION; N-TOSYLARYLIMINES; ALKYL-HALIDES; REDUCTION; CLEAVAGE; AMINES; SMI2/H2O/AMINE; MILD; ARENESULFONAMIDES; ARYLATION;

D O I：

10.1021/ol802243d

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Sml(2)amine/water mediates instantaneous cleavage of tosyl amides and tosyl esters. Highly hindered, sensitive and functionalized substrates were successfully deprotected in near quantitative yield.

引用

页码：503 / 506

页数：4

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