Potential and Limitation of HLA-Based Banking of Human Pluripotent Stem Cells for Cell Therapy

被引:70
作者
de Rham, Casimir
Villard, Jean [1 ]
机构
[1] Univ Hosp Geneva, Transplant Immunol Unit, Div Immunol & Allergy, CH-1211 Geneva 14, Switzerland
关键词
NON-HODGKIN-LYMPHOMA; TRANSPLANTATION; DONOR; LINES; IMMUNOGENICITY; INDUCTION; MOLECULES; NUMBER;
D O I
10.1155/2014/518135
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Great hopes have been placed on human pluripotent stem (hPS) cells for therapy. Tissues or organs derived from hPS cells could be the best solution to cure many different human diseases, especially those who do not respond to standard medication or drugs, such as neurodegenerative diseases, heart failure, or diabetes. The origin of hPS is critical and the idea of creating a bank of well-characterized hPS cells has emerged, like the one that already exists for cord blood. However, the main obstacle in transplantation is the rejection of tissues or organ by the receiver, due to the three main immunological barriers: the human leukocyte antigen (HLA), the ABO blood group, and minor antigens. The problem could be circumvented by using autologous stem cells, like induced pluripotent stem (iPS) cells, derived directly from the patient. But iPS cells have limitations, especially regarding the disease of the recipient and possible difficulties to handle or prepare autologous iPS cells. Finally, reaching standards of good clinical or manufacturing practices could be challenging. That is why well-characterized and universal hPS cells could be a better solution. In this review, we will discuss the interest and the feasibility to establish hPS cells bank, as well as some economics and ethical issues.
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页数:6
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共 49 条
[1]   Generation of pluripotent stem cells from adult mouse liver and stomach cells [J].
Aoi, Takashi ;
Yae, Kojiro ;
Nakagawa, Masato ;
Ichisaka, Tomoko ;
Okita, Keisuke ;
Takahashi, Kazutoshi ;
Chiba, Tsutomu ;
Yamanaka, Shinya .
SCIENCE, 2008, 321 (5889) :699-702
[2]   Molecules and mechanisms of the graft-versus-leukaemia effect [J].
Bleakley, M ;
Riddell, SR .
NATURE REVIEWS CANCER, 2004, 4 (05) :371-380
[3]   Immune Influence on Adult Neural Stem Cell Regulation and Function [J].
Carpentier, Pamela A. ;
Palmer, Theo D. .
NEURON, 2009, 64 (01) :79-92
[4]   Tolerance strategies for stem-cell-based therapies [J].
Chidgey, Ann P. ;
Layton, Daniel ;
Trounson, Alan ;
Boyd, Richard L. .
NATURE, 2008, 453 (7193) :330-337
[5]   Medical progress: Hematopoietic stem-cell transplantation [J].
Copelan, EA .
NEW ENGLAND JOURNAL OF MEDICINE, 2006, 354 (17) :1813-1826
[6]   Immunogenicity of Pluripotent Stem Cells and Their Derivatives [J].
de Almeida, Patricia E. ;
Ransohoff, Julia D. ;
Nahid, Abu ;
Wu, Joseph C. .
CIRCULATION RESEARCH, 2013, 112 (03) :549-561
[7]   How to cross immunogenetic hurdles to human embryonic stem cell transplantation [J].
de Rham, Casimir ;
Villard, Jean .
SEMINARS IN IMMUNOPATHOLOGY, 2011, 33 (06) :525-534
[8]   Human embryonic stem cells and their differentiated derivatives are less susceptible to immune rejection than adult cells [J].
Drukker, Micha ;
Katchman, Helena ;
Katz, Gil ;
Friedman, Smadar Even-Tov ;
Shezen, Elias ;
Hornstein, Eran ;
Mandelboim, Ofer ;
Reisner, Yair ;
Benvenisty, Nissim .
STEM CELLS, 2006, 24 (02) :221-229
[9]   The challenge of immunogenicity in the quest for induced pluripotency [J].
Fairchild, Paul J. .
NATURE REVIEWS IMMUNOLOGY, 2010, 10 (12) :868-875
[10]   Establishment of a Brazilian Line of Human Embryonic Stem Cells in Defined Medium: Implications for Cell Therapy in an Ethnically Diverse Population [J].
Fraga, Ana M. ;
Sukoyan, Marina ;
Rajan, Prithi ;
de Almeida Ferreira Braga, Daniela Paes ;
Iaconelli, Assumpto, Jr. ;
Franco, Jose Goncalves, Jr. ;
Borges, Edson, Jr. ;
Pereira, Lygia V. .
CELL TRANSPLANTATION, 2011, 20 (03) :431-440