Cytotoxicity of New Selenoimine, Selenonitrone, and Nitrone Derivatives Against Human Breast Cancer MDA-MB231 Cells

A series of new nitrone, selenoimine and selenonitrone derivatives were synthesized. Nitrone and selenonitrone derivatives were synthesized through the condensation reaction between N-mono substitutedhydroxylamine and carbonyl compounds substituted with electron donating groups, such as di(4-methoxy)benzoyl diselenide, 4-(N, N-dimethylamino) benzoyl selenonitrile and 4, 4'-di(N, N- dimethylamino)benzil, afforded a variety of new nitrone and selenonitrone compounds. Selenoimine derivative was synthesized through the condensation reaction between tert-butyl amine and (4-methoxybenzoyl selenonitrile). The yield of synthesized compounds (N-1, N-2, N-3, N-4 and N-5 were (66, 60, 61, 62 and 45) %, respectively. The structures of the synthesized compounds were characterized by FT-IR, H-1-NMR, C-13-NMR, and mass spectra. Cytotoxicity of selenonitrone (N-1) and selenoimine (N-3) derivatives against breast cancer cells (MDA-MB231) were evaluated for 24 and 48 h via MTT assay. The IC50 value of compound N-1 was 1.714 and 1.897 mu M for 24 h and 48 h, respectively. The IC50 value of compound N-3 was 1.438 and 2.469 mu M for 24 h and 48 h, respectively. The results suggested selenonitrone (N-1) and selenoimine (N-3) as anti-breast cancer potential lead compound with future merit investigations.