DNA Repair in Normal and Cancer Stem Cells, with Special Reference to the Central Nervous System

被引：21

作者：

Frosina, Guido ^{[1
]}

机构：

[1] Ist Nazl Ric Canc, Mol Mutagenesis & DNA Repair Unit, I-16132 Genoa, Italy

来源：

CURRENT MEDICINAL CHEMISTRY | 2009年 / 16卷 / 07期

关键词：

Stem cells; differentiation; DNA repair; CD133; cancer; NEURAL STEM/PROGENITOR CELLS; BASE EXCISION-REPAIR; IMMORTAL STRAND HYPOTHESIS; LONG-TERM MAINTENANCE; MALIGNANT GLIOMA; GENE-EXPRESSION; SELF-RENEWAL; BRAIN-TUMORS; CD133; EXPRESSION; PROGENITOR CELLS;

D O I：

10.2174/092986709787549253

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Stem cells build and maintain organisms. Accordingly, they are particularly well-protected from damage to DNA and other cellular components. This feature becomes a serious drawback when stem cells transform and develop cancer, because they resist to radiation and chemotherapy. Various mechanisms ensure protection of stem cells. In normal stem cells enhanced DNA repair is often one of them. Whether the same holds for cancer stem cells still is an open question.

引用

页码：854 / 866

页数：13

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