Superantigens as immunomodulators: recent structural insights

被引：39

作者：

Papageorgiou, AC ^{[1
]}

Acharya, KR ^{[1
]}

机构：

[1] UNIV BATH, DEPT BIOL & BIOCHEM, BATH BA2 7AY, AVON, ENGLAND

来源：

STRUCTURE | 1997年 / 5卷 / 08期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/S0969-2126(97)00252-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Superantigens interact with major histocompatibility complex (MHC) class ii molecules and T-cell receptors (TcRs) forming a trimolecular complex which is able to induce proliferation and cytokine production in T cells. Although superantigens appear to act through a common mechanism, they vary in many of their specific interactions and biological properties. X-ray crystallographic studies and biochemical experiments have now established that cross-linking of MHC class II molecules and the TcR by superantigens can occur in a number of different modes.

引用

页码：991 / 996

页数：6

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