Machine learning in precision medicine: lessons to learn

被引：23

作者：

Plant, Darren ^{[1
,2
]}

Barton, Anne ^{[1
,2
]}

机构：

[1] Manchester Univ NHS Trust, Manchester Acad Hlth Sci Ctr, NIHR Manchester Biomed Res Ctr, Manchester, Lancs, England

[2] Univ Manchester, Ctr Musculoskeletal Res, Versus Arthrit Ctr Genet & Genom, Manchester, Lancs, England

来源：

NATURE REVIEWS RHEUMATOLOGY | 2021年 / 17卷 / 01期

关键词：

D O I：

10.1038/s41584-020-00538-2

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The ability to predict how a patient might respond to a medication would shift treatment decisions away from trial and error and reduce disease-associated health and financial burdens. Machine learning approaches applied to genomic datasets offer great promise to deliver personalized medicine but their application must first be optimized.

引用

页码：5 / 6

页数：2

共 8 条

[1] Double Dipping in Machine Learning: Problems and Solutions [J].

Ball, Tali M. ;

Squeglia, Lindsay M. ;

Tapert, Susan F. ;

Paulus, Martin P. .

BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING, 2020, 5 (03) :261-263

[2]

Guyon I., 2003, J MACH LEARN RES, V3, P157

[3]

National Center for Biotechnology Information, 2020, GEN EXPR OMN DAT

[4] Minimum sample size for developing a multivariable prediction model: PART II - binary and time-to-event outcomes [J].

Riley, Richard D. ;

Snell, Kym I. E. ;

Ensor, Joie ;

Burke, Danielle L. ;

Harrell, Frank E., Jr. ;

Moons, Karel G. M. ;

Collins, Gary S. .

STATISTICS IN MEDICINE, 2019, 38 (07) :1276-1296

[5] Methods of integrating data to uncover genotype-phenotype interactions [J].

Ritchie, Marylyn D. ;

Holzinger, Emily R. ;

Li, Ruowang ;

Pendergrass, Sarah A. ;

Kim, Dokyoon .

NATURE REVIEWS GENETICS, 2015, 16 (02) :85-97

[6] Multiomics and Machine Learning Accurately Predict Clinical Response to Adalimumab and Etanercept Therapy in Patients With Rheumatoid Arthritis [J].

Tao, Weiyang ;

Concepcion, Arno N. ;

Vianen, Marieke ;

Marijnissen, Anne C. A. ;

Lafeber, Floris P. G. J. ;

Radstake, Timothy R. D. J. ;

Pandit, Aridaman .

ARTHRITIS & RHEUMATOLOGY, 2021, 73 (02) :212-222

[7] Multi-omics monitoring of drug response in rheumatoid arthritis in pursuit of molecular remission [J].

Tasaki, Shinya ;

Suzuki, Katsuya ;

Kassai, Yoshiaki ;

Takeshita, Masaru ;

Murota, Atsuko ;

Kondo, Yasushi ;

Ando, Tatsuya ;

Nakayama, Yusuke ;

Okuzono, Yuumi ;

Takiguchi, Maiko ;

Kurisu, Rina ;

Miyazaki, Takahiro ;

Yoshimoto, Keiko ;

Yasuoka, Hidekata ;

Yamaoka, Kunihiro ;

Morita, Rimpei ;

Yoshimura, Akihiko ;

Toyoshiba, Hiroyoshi ;

Takeuchi, Tsutomu .

NATURE COMMUNICATIONS, 2018, 9

[8] Integrating Clinical and Multiple Omics Data for Prognostic Assessment across Human Cancers [J].

Zhu, Bin ;

Song, Nan ;

Shen, Ronglai ;

Arora, Arshi ;

Machiela, Mitchell J. ;

Song, Lei ;

Landi, Maria Teresa ;

Ghosh, Debashis ;

Chatterjee, Nilanjan ;

Baladandayuthapani, Veera ;

Zhao, Hongyu .

SCIENTIFIC REPORTS, 2017, 7

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