A Novel Tumor Suppressor, REIC/Dkk-3 Gene Identified by Our In Vitro Transformation Model of Normal Human Fibroblasts Works as a Potent Therapeutic Anti-tumor Agent

被引：7

作者：

Sakaguchi, Masakiyo ^{[1
]}

Huh, Nam-ho ^{[1
]}

Namba, Masayoshi ^{[2
]}

机构：

[1] Okayama Univ, Dept Cell Biol, Grad Sch Med Dent & Pharmaceut Sci, Kita Ku, Okayama 7008530, Japan

[2] Niimi Coll, Niimi 7188585, Japan

来源：

HUMAN CELL TRANSFORMATION: ROLE OF STEM CELLS AND THE MICROENVIRONMENT | 2012年 / 720卷

关键词：

PROSTATE-CANCER CELLS; DOWN-REGULATION; P-GLYCOPROTEIN; REDUCED EXPRESSION; OVEREXPRESSION; APOPTOSIS; RESISTANCE; GROWTH; ACTIVATION; INDUCTION;

D O I：

10.1007/978-1-4614-0254-1_17

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Reduced Expression in Immortalized Cell (REIC) was cloned by subtractive hybridization method as a gene whose expression is reduced in many human immortalized and neoplastic tumor cells. The REIC, when overexpressed by an adenovirus (Ad-REIC), exhibited a dramatic therapeutic effect on a wide variety of human cancers through a mechanism triggered by ER-stress-mediated JNK activation. In addition to this direct effect on cancer cells, Ad-REIC exerted another cytotoxicity on human cancers, an indirect host-mediated effect due to overproduction of IL-7 by mis-targeted normal cells. This "one-bullet two-arms" finding may lead to a powerful new therapeutic approach to the treatment of human cancers.

引用

页码：209 / 215

页数：7

共 30 条

[1] Adenovirus-mediated overexpression of REIC/Dkk-3 selectively induces apoptosis in human prostate cancer cells through activation of c-Jun-NH2-kinase [J].