Genetic Polymorphisms of IL1B, IL6, and TNFα in a Chinese Han Population with Pulmonary Tuberculosis

被引:13
作者
Wu, Shouquan [1 ]
Wang, Yu [1 ]
Zhang, Miaomiao [1 ]
Shrestha, Saurav S. [2 ]
Wang, Minggui [1 ]
He, Jian-Qing [1 ]
机构
[1] Sichuan Univ, West China Hosp, Dept Resp & Crit Care Med, Chengdu, Sichuan, Peoples R China
[2] Sichuan Univ, West China Hosp, Dept Radiol, Chengdu, Sichuan, Peoples R China
基金
高等学校博士学科点专项科研基金; 中国国家自然科学基金;
关键词
SUSCEPTIBILITY; ASSOCIATION; EXPRESSION; IL-6; INTERLEUKIN-6; TRANSCRIPTION; INFLAMMATION; ARTHRITIS; THERAPY; TISSUE;
D O I
10.1155/2018/3010898
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Background. The factors that predispose to pulmonary tuberculosis (PTB) are not fully understood. Previous studies have shown that cytokine gene polymorphisms were associatedwith PTB. Objectives. In this study, we have investigated the relationship between ILB, IL6, and TNF alpha polymorphisms and a predisposition to Mycobacterium tuberculosis (MTB) infection and PTB. Methods. A total of 209 cases of PTB, 201 subjects with latent TB infection (LTBI), and 204 healthy controls (HCS) were included in this study. Logistic regression analyses under allelic, homozygous, and heterozygous models were used to calculate.. values, odds ratios (ORs), and 95% confidence intervals (CIs) for assessing the association between single nucleotide polymorphisms (SNPs) and disease risk, adjusting for sex and age. Genotyping was conducted using the improved multiplex ligase detection reaction (iMLDR) method. Results. When comparing PTB patients with LTBI subjects, significant associations with disease development were observed for SNPs of IL6 and TNF alpha When comparing LTBI subjects with HCS, IL1B polymorphisms were significantly associated with LIBI. Haplotype analyses suggested that the CGG haplotype of IL1B was associated with an increased risk of PTB (p=0.039, OR = 1.34, 95% CI: 1.01-1.76), while the TTGCG haplotype of TNF alpha. was a protective factor against PTB (p=0.039, OR = 0.66, 95% CI: 0.44-0.98). Conclusion. Our study demonstrated that IL1B variants were related to LTBI and IL6 and TNF alpha variants were associated with PTB.
引用
收藏
页数:10
相关论文
共 41 条
[1]   Innate Immune Gene Polymorphisms in Tuberculosis [J].
Azad, Abul K. ;
Sadee, Wolfgang ;
Schlesinger, Larry S. .
INFECTION AND IMMUNITY, 2012, 80 (10) :3343-3359
[2]   Genetic background affects the expansion of macrophage subsets in the lungs of Mycobacterium tuberculosis-infected hosts [J].
Bertolini, Thais Barboza ;
de Souza, Alexandre Ignacio ;
Gembre, Ana Flavia ;
Pineros, Annie Rocio ;
Prado, Rafael de Queiroz ;
Silva, Joao Santana ;
Zambelli Ramalho, Leandra Naira ;
Deperon Bonato, Vania Luiza .
IMMUNOLOGY, 2016, 148 (01) :102-113
[3]   Inflammation and the coagulation system in tuberculosis: Tissue Factor leads the dance [J].
Caccamo, Nadia ;
Dieli, Francesco .
EUROPEAN JOURNAL OF IMMUNOLOGY, 2016, 46 (02) :303-306
[4]   Interleukin-1β polymorphisms in Colombian patients with autoimmune rheumatic diseases [J].
Camargo, JF ;
Correa, PA ;
Castiblanco, J ;
Anaya, JM .
GENES AND IMMUNITY, 2004, 5 (08) :609-614
[5]   High IL-6 and low IL-15 levels mark the presence of TB infection: A preliminary study [J].
Chandrashekara, S. ;
Anupama, K. R. ;
Sambarey, Awanti ;
Chandra, Nagasuma .
CYTOKINE, 2016, 81 :57-62
[6]   Single nucleotide polymorphisms in the human interleukin-1B gene affect transcription according to haplotype context [J].
Chen, HM ;
Wilkins, LM ;
Aziz, N ;
Cannings, C ;
Wyllie, DH ;
Bingle, C ;
Rogus, J ;
Beck, JD ;
Offenbacher, S ;
Cork, MJ ;
Rafie-Kolpin, M ;
Hsieh, CM ;
Kornman, KS ;
Duff, GW .
HUMAN MOLECULAR GENETICS, 2006, 15 (04) :519-529
[7]   Mycobacterium tuberculosis Upregulates TNF-α Expression via TLR2/ERK Signaling and Induces MMP-1 and MMP-9 Production in Human Pleural Mesothelial Cells [J].
Chen, Wei-Lin ;
Sheu, Joen-Rong ;
Chen, Ray-Jade ;
Hsiao, Shih-Hsin ;
Hsiao, Che-Jen ;
Chou, Yung-Chen ;
Chung, Chi-Li ;
Hsiao, George .
PLOS ONE, 2015, 10 (09)
[8]   Genetic Polymorphisms in Inflammasome-Dependent Innate Immunity among Pediatric Patients with Severe Renal Parenchymal Infections [J].
Cheng, Chi-Hui ;
Lee, Yun-Shien ;
Chang, Chee-Jen ;
Lin, Jui-Che ;
Lin, Tzou-Yien .
PLOS ONE, 2015, 10 (10)
[9]   IL1 and TNF gene polymorphisms in patients with juvenile idiopathic arthritis treated with TNF inhibitors [J].
Cimaz, Rolando ;
Cazalis, Marie-Angelique ;
Reynaud, Charlotte ;
Gerloni, Valeria ;
Zulian, Francesco ;
Biggioggero, Martina ;
Martini, Giorgia ;
Pontikaki, Irene ;
Fantini, Flavio ;
Mougin, Bruno ;
Miossec, Pierre .
ANNALS OF THE RHEUMATIC DISEASES, 2007, 66 (07) :900-904
[10]   The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis [J].
Fishman, D ;
Faulds, G ;
Jeffery, R ;
Mohamed-Ali, V ;
Yudkin, JS ;
Humphries, S ;
Woo, P .
JOURNAL OF CLINICAL INVESTIGATION, 1998, 102 (07) :1369-1376