Cytotoxic activity of aminoderivatized cationic chitosan derivatives

被引：61

作者：

Lee, JK

Lim, HS

Kim, JH

机构：

[1] Korea Adv Inst Sci & Technol, Dept Biol Sci, Taejon 449791, South Korea

[2] BioNgene Co Ltd, Seoul 110521, South Korea

[3] Yosu Natl Univ, Div Biotechnol & Chem Engn, Jeosu Jeollanam Do 550749, South Korea

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 20期

关键词：

D O I：

10.1016/S0960-894X(02)00530-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Chitosan derivatives were prepared by dialkylaminoalkylation and reductive amination followed by quaternization. In this study, the cytotoxic activity of the chitosan derivatives was investigated and a relationship between structure and activity is suggested. The cationic chitosan derivatives elicited dose-dependent inhibitory effects on the proliferation of tumor cell lines. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：2949 / 2951

页数：3

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