Chromones from the Endophytic Fungus Pestalotiopsis sp Isolated from the Chinese Mangrove Plant Rhizophora mucronata

被引：114
|
作者：
Xu, Jing [1 ,2 ]
Kjer, Julia [1 ]
Sendker, Jandirk [1 ]
Wray, Victor [3 ]
Guan, Huashi [2 ]
Edrada, RuAngelie [5 ]
Lin, Wenhan [6 ]
Wu, Jun [4 ]
Proksch, Peter [1 ]
机构：
[1] Univ Dusseldorf, Inst Pharmazeut Biol & Biotechnol, D-40225 Dusseldorf, Germany
[2] Ocean Univ China, Chinese Minist Educ, Inst Marine Drugs & Food, Key Lab Marine Drugs, Qingdao 266003, Peoples R China
[3] Helmholtz Ctr Infect Res, Dept Biol Struct, D-38124 Braunschweig, Germany
[4] Chinese Acad Sci, Key Lab Marine Bioresources Sustainable Utilizat, S China Sea Inst Oceanol, Guangzhou 510301, Guangdong, Peoples R China
[5] Univ Strathclyde, Strathclyde Inst Pharm & Biomed Sci, Glasgow G4 0NR, Lanark, Scotland
[6] Peking Univ, Natl Res Labs Nat & Biomimet Drugs, Hlth Sci Ctr, Beijing 100083, Peoples R China
来源：
JOURNAL OF NATURAL PRODUCTS | 2009年 / 72卷 / 04期
关键词：
METABOLITES; MICROSPORA; PRODUCTS; ACID;
D O I：
10.1021/np800748u
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Six new chromones, named pestalotiopsones A-F (1-6), and the known derivative 7-hydroxy-2-(2-hydroxypropyl)-5-methylchromone (7) were obtained from the mycelia and culture filtrate of the mangrove endophytic fungus Pestalotiopsis sp., which was isolated from leaves of the Chinese Mangrove plant Rhizophora mucronata. Their structures were elucidated on the basis of spectroscopic data. Pestalotiopsones A-F are chromones having both an alkyl side chain substituted at C-2 and a free or substituted carboxyl group at C-5. Compound 6 exhibited moderate cytotoxicity against the murine cancer cell line L5178Y, whereas the other investigated compounds proved to be inactive.
引用
收藏
页码：662 / 665
页数：4
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