HIV Antibody Characterization as a Method to Quantify Reservoir Size During Curative Interventions

被引：47

作者：

Burbelo, Peter D. ^{[1
]}

Bayat, Ahmad ^{[2
]}

Rhodes, Craig S. ^{[3
]}

Hoh, Rebecca ^{[4
]}

Martin, Jeffrey N. ^{[4
,5
]}

Fromentin, Remi ^{[6
]}

Chomont, Nicolas ^{[6
]}

Huetter, Gero ^{[7
]}

Kovacs, Joseph A. ^{[8
]}

Deeks, Steven G. ^{[4
]}

机构：

[1] NIDCR, Clin Dent Res Core, Bethesda, MD 20892 USA

[2] NIH, Dept Perioperat Med, Ctr Clin, Bethesda, MD 20892 USA

[3] Natl Inst Dent & Craniofacial Res, Lab Dev Biol, San Francisco, CA USA

[4] Univ Calif San Francisco, Dept Med, San Francisco, CA USA

[5] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA

[6] Vaccine & Gene Therapy Inst Florida, Port St Lucie, FL USA

[7] Heidelberg Univ, Inst Transfus Med & Immunol, Mannheim, Germany

[8] NIH, Crit Care Med Dept, NIH Clin Ctr, Bethesda, MD 20892 USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 2014年 / 209卷 / 10期

基金：

美国国家卫生研究院;

关键词：

antibodies; elite controllers; HIV-1; persistence; serology; viral reservoirs; INFECTION; THERAPY; QUANTIFICATION; REPLICATION; PERSISTENCE;

D O I：

10.1093/infdis/jit667

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Quantitative humoral profiling of recent samples from a human immunodeficiency virus (HIV)-infected adult who was cured following a delta32/delta32 CCR5 stem cell transplant in 2007 revealed no antibodies against p24, matrix, nucleocapsid, integrase, protease, and gp120, but low levels of antibodies against reverse transcriptase, tat, and gp41. Antibody levels to these HIV proteins persisted at high and stable levels in most noncontrollers, elite controllers, and antiretroviral-treated subjects, but a rare subset of controllers had low levels of antibodies against matrix, reverse transcriptase, integrase, and/or protease. Comprehensive HIV antibody profiles may prove useful for monitoring curative interventions.

引用

收藏

页码：1613 / 1617

页数：5

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