Preparation and Biofunctionalization of Multicolor Conjugated Polymer Nanoparticles for Imaging and Detection of Tumor Cells

被引：146

作者：

Feng, Liheng ^{[1
,2
]}

Liu, Libing ^{[2
]}

Lv, Fengting ^{[2
]}

Bazan, Guillermo C. ^{[3
,4
]}

Wang, Shu ^{[2
]}

机构：

[1] Shanxi Univ, Sch Chem & Chem Engn, Taiyuan 030006, Peoples R China

[2] Chinese Acad Sci, Beijing Natl Lab Mol Sci, Key Lab Organ Solids, Inst Chem, Beijing 100190, Peoples R China

[3] Univ Calif Santa Barbara, Ctr Polymers & Organ Solids, Dept Chem & Biochem, Santa Barbara, CA 93106 USA

[4] Univ Calif Santa Barbara, Ctr Polymers & Organ Solids, Dept Mat, Santa Barbara, CA 93106 USA

来源：

ADVANCED MATERIALS | 2014年 / 26卷 / 23期

关键词：

DOTS; FLUORESCENCE; ANTICANCER; DELIVERY; PROTEIN;

D O I：

10.1002/adma.201305206

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Multicolor conjugated polymer nanoparticles (CPNs) are designed and bio-functionalized with antibody for targeted cell imaging and cell detection. In comparison to single-antibody recognition mode to tumor cells, enhanced specificity for targeted imaging and detection of tumor cells is achieved by binding two antibody functionalized CPNs to one tumor cell. This strategy provides a new platform for designing CPNs useful for targeted imaging, cells detection and other biological applications.

引用

页码：3926 / 3930

页数：5

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