Understanding Drug Sensitivity and Tackling Resistance in Cancer

被引：40

作者：

Tyner, Jeffrey W. ^{[1
,2
]}

Haderk, Franziska ^{[3
,4
,5
]}

Kumaraswamy, Anbarasu ^{[6
]}

Baughn, Linda B. ^{[7
]}

Van Ness, Brian ^{[8
]}

Liu, Song ^{[9
]}

Marathe, Himangi ^{[9
]}

Alumkal, Joshi J. ^{[6
]}

Bivona, Trever G. ^{[3
,4
,5
]}

Chan, Keith Syson ^{[10
,11
]}

Druker, Brian J. ^{[1
,2
]}

Hutson, Alan D. ^{[9
]}

Nelson, Peter S. ^{[12
,13
]}

Sawyers, Charles L. ^{[14
,15
]}

Willey, Christopher D. ^{[16
]}

机构：

[1] Oregon Hlth & Sci Univ, Knight Canc Inst, Portland, OR 97239 USA

[2] Oregon Hlth & Sci Univ, Dept Cell Dev & Canc Biol, Portland, OR 97239 USA

[3] Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA

[4] Univ Calif San Francisco, Helen Diller Family Comprehens Canc Ctr, San Francisco, CA 94143 USA

[5] Univ Calif San Francisco, Dept Cellular & Mol Pharmacol, San Francisco, CA 94143 USA

[6] Univ Michigan, Rogel Canc Ctr, Ann Arbor, MI 48109 USA

[7] Mayo Clin, Div Hematopathol, Dept Lab Med & Pathol, Rochester, MN USA

[8] Univ Minnesota, Dept Genet Cell Biol & Dev, Minneapolis, MN USA

[9] Roswell Park Comprehens Canc Ctr, Dept Biostat & Bioinformat, New York, NY USA

[10] Cedars Sinai Samuel Oschin Comprehens Canc Inst, Los Angeles, CA USA

[11] Cedars Sinai Med Ctr, Dept Pathol & Lab Med, Los Angeles, CA 90048 USA

[12] Univ Washington, Dept Med, Div Oncol, Seattle, WA 98195 USA

[13] Fred Hutchinson Canc Res Ctr, Div Human Biol, 1124 Columbia St, Seattle, WA 98104 USA

[14] Mem Sloan Kettering Canc Ctr, Human Oncol & Pathogenesis Program, 1275 York Ave, New York, NY 10021 USA

[15] Howard Hughes Med Inst, Chevy Chase, MD USA

[16] Univ Alabama Birmingham, Dept Radiat Oncol, Birmingham, AL USA

来源：

CANCER RESEARCH | 2022年 / 82卷 / 08期

关键词：

CELL LUNG-CANCER; TYROSINE KINASE INHIBITORS; GROWTH-FACTOR RECEPTOR; TUMOR-MICROENVIRONMENT; TARGETED THERAPY; PROSTATE-CANCER; INTRATUMOR HETEROGENEITY; BORTEZOMIB RESISTANCE; MULTIDRUG-RESISTANCE; PROMOTES RESISTANCE;

D O I：

10.1158/0008-5472.CAN-21-3695

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Decades of research into the molecular mechanisms of cancer and the development of novel therapeutics have yielded a number of remarkable successes. However, our ability to broadly assign effective, rationally targeted therapies in a personalized manner remains elusive for many patients, and drug resistance persists as a major problem. This is in part due to the well-documented heterogeneity of cancer, including the diversity of tumor cell lineages and cell states, the spectrum of somatic mutations, the complexity of microenvironments, and immune-suppressive features and immune repertoires, which collectively require numerous different therapeutic approaches. Here, we describe a framework to understand the types and biological causes of resistance, providing translational opportunities to tackle drug resistance by rational therapeutic strategies.

引用

页码：1448 / 1460

页数：13

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